Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity
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DOI: 10.1136/jitc-2020-001846
Abstract: Background Tumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senescence process… read more here.
Keywords: enhances metabolic; metabolic cellular; antitumor; cell ... See more keywords