Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-induced apoptosis through upregulation of Bim expression.
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DOI: 10.1016/j.bbrc.2018.03.068
Abstract: Inhibition of cathespsin S not only inhibits invasion and angiogenesis, but also induces apoptosis and autophagy in cancer cells. In present study, we revealed that pharmacological inhibitor [Z-FL-COCHO (ZFL)] of cathepsin S up-regulates pro-apoptotic protein… read more here.
Keywords: enhances oxaliplatin; inhibitor; bim expression; apoptosis ... See more keywords