An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances Splicing.
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DOI: 10.1016/j.celrep.2017.06.035
Abstract: Tumor necrosis factor alpha (TNF-α) is expressed promptly during inflammatory responses. Efficient TNF-α mRNA splicing is achieved through a 3' UTR element that activates RNA-dependent eIF2α protein kinase (PKR). The TNF-α RNA activator, we show,… read more here.
Keywords: enhances splicing; potently enhances; mrna splicing; eif2 phosphorylation ... See more keywords