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Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design†‡

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0 Published in 2020 at "Chemical Science"

DOI: 10.1039/d0sc04297h

Abstract: Single site OH → F substitution at the termini of maltotetraose leads to significantly improved hydrolytic stability towards α-amylase and α-glucosidase relative to the natural compound. To explore the effect of molecular editing, selectively modified… read more here.

Keywords: orientation; glycan stability; fluorination; site ... See more keywords