Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form
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DOI: 10.1016/j.nbd.2017.07.007
Abstract: The pathology of Parkinson's disease and other synucleinopathies is characterized by the formation of intracellular inclusions comprised primarily of misfolded, fibrillar α-synuclein (α-syn). One strategy to slow disease progression is to prevent the misfolding and… read more here.
Keywords: aggregation; inhibits aggregation; enhancing reconfiguration; pathology ... See more keywords