Transcription control by the ENL YEATS domain in acute leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21688
Abstract: Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies a dependency on… read more here.
Keywords: transcription control; enl; yeats domain; acute leukaemia ... See more keywords
Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50171-w
Abstract: How disruptions to normal cell differentiation link to tumorigenesis remains incompletely understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis, often harbors mutations in epigenetic regulators, but their role in kidney development remains unexplored.… read more here.
Keywords: enl; single cell; cell; rewiring gene ... See more keywords
Abstract A013: Prioritization of Eleven-Nineteen-Leukemia (ENL) inhibitors as orally available drug candidates for acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.cancerchem24-a013
Abstract: Acute myeloid leukemia (AML) is the second most prevalent and fatal form of leukemia. The growth of AML cells harboring oncogenic MLL rearrangements relies on The YEATS domain-containing protein ENL. Many small molecule inhibitors targeting… read more here.
Keywords: enl; acute myeloid; prioritization eleven; leukemia ... See more keywords
Regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010641
Abstract: Background The numbers of circulating regulatory T cells (Tregs) are increased in lepromatous leprosy (LL) but reduced in erythema nodosum leprosum (ENL), the inflammatory complication of LL. It is unclear whether the suppressive function of… read more here.
Keywords: function; cd25 cells; cd25; depletion cd25 ... See more keywords
Toxoplasma gondii infection and high levels of IgE are associated to erythema nodosum leprosy (ENL)
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0300704
Abstract: Leprosy is a chronic infectious disease caused by the bacillus Mycobacterium leprae. The disease may evolve for inflammatory reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL), the major cause of irreversible neuropathy in leprosy,… read more here.
Keywords: erythema nodosum; toxoplasma gondii; gondii infection; enl ... See more keywords
Neutrophil NETworking in ENL: Potential as a Putative Biomarker: Future Insights
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.697804
Abstract: Erythema nodosum leprosum (ENL), also known as type 2 reaction (T2R) is an immune complex mediated (type III hypersensitivity) reactional state encountered in patients with borderline lepromatous and lepromatous leprosy (BL and LL) either before,… read more here.
Keywords: networking enl; biomarker; treatment; enl ... See more keywords
Effect of a Flaxseed Lignan Intervention on Circulating Bile Acids in a Placebo-Controlled Randomized, Crossover Trial
Sign Up to like & getrecommendations! Published in 2020 at "Nutrients"
DOI: 10.3390/nu12061837
Abstract: Plant lignans and their microbial metabolites, e.g., enterolactone (ENL), may affect bile acid (BA) metabolism through interaction with hepatic receptors. We evaluated the effects of a flaxseed lignan extract (50 mg/day secoisolariciresinol diglucoside) compared to… read more here.
Keywords: intervention; metabolism; randomized crossover; enl ... See more keywords