Oxygenated Cyclopentenones via the Pauson–Khand Reaction of Silyl Enol Ether Substrates
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DOI: 10.1021/acs.orglett.2c00856
Abstract: We report here the application of silyl enol ether moieties as efficient alkene coupling partners within cobalt-mediated intramolecular Pauson–Khand reactions. This cyclization strategy delivers synthetically valuable oxygenated cyclopentenone products in yields of ≤93% from both… read more here.
Keywords: enol ether; pauson khand; oxygenated cyclopentenones; silyl enol ... See more keywords
Synthesis of 3-Azidopiperidine Skeleton Employing Ceric Ammonium Nitrate (CAN)-Mediated Regioselective Azidoalkoxylation of Enol Ether: Total Synthesis of D2 Receptor Agonist (±)-Quinagolide.
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DOI: 10.1021/acs.orglett.8b02900
Abstract: The total synthesis of (±)-quinagolide, which is a D2 receptor agonist, was accomplished via a ceric ammonium nitrate (CAN)-mediated regioselective azidoalkoxylation of enol ether route. Key features of the synthesis include Claisen rearrangement, PPTS (pyridinium… read more here.
Keywords: azidoalkoxylation enol; mediated regioselective; regioselective azidoalkoxylation; enol ether ... See more keywords