Chemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives: Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.09.008
Abstract: In efforts to develop new antitubercular agents, we report here the synthesis of a series of novel pyrrole hydrazine derivatives. The molecules were evaluated against inhibitors of InhA, which is one of the key enzymes… read more here.
Keywords: novel; acp reductase; enoyl acp; synthesis ... See more keywords
Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46696
Abstract: Novel chemotherapeutics agents are needed to kill Mycobacterium tuberculosis, the main causative agent of tuberculosis (TB). The M. tuberculosis 2-trans-enoyl-ACP(CoA) reductase enzyme (MtInhA) is the druggable bona fide target of isoniazid. New chemotypes were previously… read more here.
Keywords: acp coa; thermodynamics; enoyl acp; tuberculosis ... See more keywords
Unsaturated fatty acid synthesis in Enterococcus faecalis requires a specific enoyl‐ACP reductase
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Microbiology"
DOI: 10.1111/mmi.14981
Abstract: The Enterococcus faecalis genome contains two enoyl‐ACP reductases genes, fabK and fabI, which encode proteins having very different structures. Enoyl‐ACP reductase catalyzes the last step of the elongation cycle of type II fatty acid synthesis… read more here.
Keywords: acid synthesis; enoyl acp; acp reductase; unsaturated fatty ... See more keywords
Synthesis, Molecular Docking Study, and Biological Evaluation of New 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N’-(2-(substituted)acetyl)benzohydrazides as Dual Enoyl ACP Reductase and DHFR Enzyme Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12040763
Abstract: In this study, a new series of 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N′-(2-(substituted)acetyl) benzohydrazides (5a–n) were prepared and new heterocycles underwent thorough characterization and evaluation for antibacterial activity; some of them underwent further testing for in vitro inhibition of enoyl… read more here.
Keywords: dimethyl pyrrol; enoyl acp; acp reductase; dhfr ... See more keywords