Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112402
Abstract: Tuberculosis remains the most deadly infectious disease worldwide due to the emergence of drug-resistant strains of Mycobacterium tuberculosis. Hence, there is a great need for more efficient treatment regimens. Herein, we carried out rational molecular… read more here.
Keywords: carrier protein; protein reductase; acyl carrier; tuberculosis ... See more keywords
Biochemical and Structural Insights Concerning Triclosan Resistance in a Novel YX7K Type Enoyl-Acyl Carrier Protein Reductase from Soil Metagenome
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DOI: 10.1038/s41598-019-51895-2
Abstract: Enoyl-acyl carrier protein reductase (ENR) catalyzes the last reduction step in the bacterial type II fatty acid biosynthesis cycle. ENRs include FabI, FabL, FabL2, FabK, and FabV. Previously, we reported a unique triclosan (TCL) resistant… read more here.
Keywords: carrier protein; acyl carrier; resistance; enoyl acyl ... See more keywords
Tryptanthrin Analogues as Inhibitors of Enoyl-acyl Carrier Protein Reductase: Activity against Mycobacterium tuberculosis, Toxicity, Modeling of Enzyme Binding.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190304125740
Abstract: BACKGROUND High numbers of infection with resistant forms of Micobacterium tuberculosis (Mtb) contribute to a constant growing demand in new highly active and effective therapeutics. Current drug discovery efforts directed towards new antituberculosis agents include… read more here.
Keywords: carrier protein; acyl carrier; toxicity; enoyl acyl ... See more keywords
Design and In-Silico Screening of Short Antimicrobial Peptides (Amps) as Anti-Tubercular Agents Targeting INHA
Sign Up to like & getrecommendations! Published in 2023 at "Current Bioinformatics"
DOI: 10.2174/1574893618666230419081901
Abstract: Tuberculosis has been studied as a potentially serious bacterial infection affecting the lung caused by Mycobacterium tuberculosis. In addition to its severe impact on health, resistance to existing drugs has also been seen as a… read more here.
Keywords: mycobacterium tuberculosis; tuberculosis; nadh dependent; dependent enoyl ... See more keywords
Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Molecular Docking
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094706
Abstract: Tuberculosis (TB) caused by Mycobacterium tuberculosis is still a serious public health concern around the world. More treatment strategies or more specific molecular targets have been sought by researchers. One of the most important targets… read more here.
Keywords: mycobacterium tuberculosis; acyl carrier; tuberculosis; inha ... See more keywords
Structure-Based Design and Pharmacophore-Based Virtual Screening of Combinatorial Library of Triclosan Analogues Active against Enoyl-Acyl Carrier Protein Reductase of Plasmodium falciparum with Favourable ADME Profiles
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24086916
Abstract: Cost-effective therapy of neglected and tropical diseases such as malaria requires everlasting drug discovery efforts due to the rapidly emerging drug resistance of the plasmodium parasite. We have carried out computational design of new inhibitors… read more here.
Keywords: plasmodium; pharmacophore; combinatorial library; design ... See more keywords
Docking-Based Virtual Screening and Molecular Dynamics Simulations of Quercetin Analogs as Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors of Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientia Pharmaceutica"
DOI: 10.3390/scipharm89020020
Abstract: The emergence of multidrug-resistant Mycobacterium tuberculosis (MTB) has become a major problem in treating tuberculosis (TB) and shows the need to develop new and efficient drugs for better TB control. This study aimed to use… read more here.
Keywords: carrier protein; mycobacterium tuberculosis; acyl carrier; tuberculosis ... See more keywords