Predictors of response to full agonist opioids in enriched enrollment randomized withdrawal clinical trials: a participant-level data meta-analysis.
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DOI: 10.1097/j.pain.0000000000003803
Abstract: ABSTRACT This study aims to identify predictors of success in treating chronic pain patients with full agonist opioids by analyzing harmonized individual patient data from 5594 participants in 9 enriched enrollment randomized withdrawal clinical trials… read more here.
Keywords: agonist opioids; randomized withdrawal; withdrawal clinical; enriched enrollment ... See more keywords
Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials
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DOI: 10.2147/jpr.s160255
Abstract: Introduction Opioids have been used for millennia for the treatment of pain. However, the long-term efficacy of opioids to treat chronic non-cancer pain continues to be debated. To evaluate opioids’ efficacy in chronic non-cancer pain,… read more here.
Keywords: enrollment randomized; enriched enrollment; efficacy opioids; chronic pain ... See more keywords
Study Design Characteristics and Endpoints for Enriched Enrollment Randomized Withdrawal Trials for Chronic Pain Patients: A Systematic Review
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DOI: 10.2147/jpr.s334840
Abstract: Abstract Enriched enrollment randomized withdrawal (EERW) pain trials are designed to include only responders with considerable pain relief without unacceptable side effects into the randomized phase. There are no recommendations for primary endpoints in such… read more here.
Keywords: time ltr; randomized withdrawal; pain; enrollment randomized ... See more keywords