Ensemble-function relationships to dissect mechanisms of enzyme catalysis
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DOI: 10.1126/sciadv.abn7738
Abstract: Decades of structure-function studies have established our current extensive understanding of enzymes. However, traditional structural models are snapshots of broader conformational ensembles of interchanging states. We demonstrate the need for conformational ensembles to understand function,… read more here.
Keywords: function; relationships dissect; function relationships; ensemble function ... See more keywords
Insights into Muscle Contraction Derived from the Effects of Small-Molecular Actomyosin-Modulating Compounds
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012084
Abstract: Bottom-up mechanokinetic models predict ensemble function of actin and myosin based on parameter values derived from studies using isolated proteins. To be generally useful, e.g., to analyze disease effects, such models must also be able… read more here.
Keywords: effects small; contraction; small molecular; actomyosin ... See more keywords