Molecular ensembles make evolution unpredictable
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DOI: 10.1073/pnas.1711927114
Abstract: Significance A long-standing goal in evolutionary biology is predicting evolution. Here, we show that the architecture of macromolecules fundamentally limits evolutionary predictability. Under physiological conditions, macromolecules, like proteins, flip between multiple structures, forming an ensemble… read more here.
Keywords: protein; evolution; molecular ensembles; relative probabilities ... See more keywords