Numerical analysis of apparent decitabine uptake in HCT116 cells: Incorporation of a bidirectional first-order kinetic parameter for ENT1 transport and Michaelis-Menten parameters for subsequent phosphorylation.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2019.10.002
Abstract: Decitabine (DAC), a DNA methylation inhibitor, is transported into cancer cells mainly via equilibrative nucleoside transporter 1 (ENT1) and subsequently phosphorylated by deoxycytidine kinase (dCK). We previously reported that apparent DAC uptake into cells may be… read more here.
Keywords: michaelis menten; hct116 cells; menten parameters; subsequent phosphorylation ... See more keywords
Targeting ENT1 and adenosine tone for the treatment of Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddw402
Abstract: &NA; Huntington's disease (HD) is caused by an abnormal CAG expansion in the exon 1 of huntingtin gene. The treatment of HD is an unmet medical need. Given the important role of adenosine in modulating… read more here.
Keywords: adenosine tone; ent1; adenosine; huntington disease ... See more keywords