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Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02267-y
Abstract: In the pharmacotherapy of patients with Parkinson’s disease (PD), entacapone reduces the peripheral metabolism of l-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t1/2) of l-dopa and increasing the area under the concentration curve (AUC).…
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Keywords:
catechol methyltransferase;
val158met polymorphism;
dopa;
entacapone ... See more keywords
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Published in 2018 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx219
Abstract: We have developed an animal model of amodiaquine-induced liver injury that has characteristics very similar to idiosyncratic drug-induced liver injury (IDILI) in humans by impairing immune tolerance using a PD1-/- mouse and cotreatment with anti-CTLA-4.…
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Keywords:
troglitazone;
tolcapone;
pioglitazone;
entacapone ... See more keywords
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Published in 2018 at "Journal of food science"
DOI: 10.1111/1750-3841.14294
Abstract: The risk for breast and colon cancer may be lowered in part by high intake of fruits and vegetables. Fruits such as grapes are abundant in bioactive compounds such as anthocyanins. The potential anticancer activity…
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Keywords:
entacapone;
growth inhibitory;
cancer cell;
cancer ... See more keywords
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Published in 2018 at "Current Science"
DOI: 10.18520/cs/v114/i03/644-649
Abstract: A rapid, specific, sensitive and robust method for entacapone-related substances in carbidopa, entacapone and levodopa film-coated tablet was developed using ACQUITY UPLC with BEH C18 column. Mobile phase (A), i.e. 0.1% orthophosphoric acid and mobile…
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Keywords:
method entacapone;
stability indicating;
method;
entacapone ... See more keywords
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Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.837019
Abstract: Background and Aims Entacapone, one of the most common drugs distributed among patients with Parkinson’s disease, is a peripherally acting catechol-O-methyltransferase (COMT) inhibitor that is used in addition to levodopa to control symptoms. However, there…
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Keywords:
side effects;
entacapone;
pilot study;