Association between Entamoeba histolytica infection and human leukocyte antigen HLA- DRB1
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2018.10.019
Abstract: Background Entamoeba histolytica is the parasitic amoeba which caused amebiasis in human and responsible of 100,000 deaths every year. There is currently no vaccine against this parasite. The innate and adaptive immunity are important in… read more here.
Keywords: entamoeba histolytica; hla drb1; histolytica infection;
Structural analysis of EhPSP in complex with 3-phosphoglyceric acid from Entamoeba histolytica reveals a basis for its lack of phosphoglycerate mutase activity.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.153
Abstract: Entamoeba histolytica phosphoserine phosphatase (EhPSP), a regulatory enzyme in the serine biosynthetic pathway, is also a structural homolog of cofactor-dependent phosphoglycerate mutase (dPGM). However, despite sharing many of its catalytic residues with dPGM, EhPSP displays… read more here.
Keywords: ehpsp; ehpsp complex; phosphoglycerate mutase; entamoeba histolytica ... See more keywords
Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
Sign Up to like & getrecommendations! Published in 2018 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2018.02.004
Abstract: The Coenzyme A (CoA), as a cofactor involved in >100 metabolic reactions, is essential to the basic biochemistry of life. Here, we investigated the CoA biosynthetic pathway of Entamoeba histolytica (E. histolytica), an enteric protozoan… read more here.
Keywords: pank; pantothenate kinase; kinase; novel anti ... See more keywords
A lysosomal hydrolase receptor, CPBF2, is associated motility and invasion of the enteric protozoan parasite Entamoeba histolytica.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2020.111299
Abstract: Proper targeting and secretion of lysosomal hydrolases are regulated by transporting receptors. Entamoeba histolytica, the enteric protozoan parasite responsible for human amebiasis, has a unique family of lysosomal hydrolase receptors, cysteine protease binding protein family,… read more here.
Keywords: invasion; hydrolase; motility; entamoeba histolytica ... See more keywords
IL-17A contributes to reducing IFN-γ/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis.
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology international"
DOI: 10.1016/j.parint.2017.09.011
Abstract: Amebiasis is an infectious disease caused by Entamoeba histolytica, an anaerobic protozoan parasite, and is a major public health problem worldwide, particularly in areas with inadequate sanitation and poor hygiene. Th1 responses, represented by interferon… read more here.
Keywords: entamoeba histolytica; ifn ratio; 17a contributes; intestinal amebiasis ... See more keywords
External pH Variations Modify Proliferation, Erythrophagocytosis, Cytoskeleton Remodeling, and Cell Morphology of Entamoeba histolytica Trophozoites.
Sign Up to like & getrecommendations! Published in 2022 at "Protist"
DOI: 10.1016/j.protis.2022.125857
Abstract: To infect the human host, Entamoeba histolytica carries out processes requiring cytoskeleton remodeling, which involves reorganizing the actin fibers. However, little is known about the external influence factors, e.g., the pH, on the parasite's cytoskeleton… read more here.
Keywords: remodeling cell; cell morphology; cytoskeleton remodeling; cytoskeleton ... See more keywords
Crosstalk between Entamoeba histolytica and the human intestinal tract during amoebiasis
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology"
DOI: 10.1017/s0031182017002190
Abstract: Abstract The protozoan parasite Entamoeba histolytica is the microbial agent of amoebiasis – an infection that is endemic worldwide and is associated with high morbidity and mortality rates. As the disease develops, virulent E. histolytica… read more here.
Keywords: crosstalk entamoeba; amoebiasis; entamoeba histolytica; histolytica human ... See more keywords
Vitamin supplementation increases the virulence of Entamoeba histolytica grown axenically
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DOI: 10.1017/s0031182020000013
Abstract: Abstract As a consequence of axenic growth and the elimination of accompanying bacterial flora, Entamoeba histolytica virulence decreases rapidly, and pathogenicity is lost. This paper evaluated the impact of vitamin supplementation on the pathogenicity of… read more here.
Keywords: growth; supplementation increases; entamoeba histolytica; vitamin supplementation ... See more keywords
Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-019-0233-6
Abstract: Even though Entamoeba histolytica (Eh)-induced host pro-inflammatory responses play a critical role in disease, we know very little about the host factors that regulate this response. Direct contact between host cell and Eh signify the… read more here.
Keywords: hmgb1; alarmin molecule; host; innate host ... See more keywords
Investigation of pyrophosphate versus ATP substrate selection in the Entamoeba histolytica acetate kinase
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DOI: 10.1038/s41598-017-06156-5
Abstract: AbstractAcetate kinase (ACK; E.C. 2.7.2.1), which catalyzes the interconversion of acetate and acetyl phosphate, is nearly ubiquitous in bacteria but is present only in one genus of archaea and certain eukaryotic microbes. All ACKs utilize… read more here.
Keywords: kinase; entamoeba histolytica; acetate; atp ... See more keywords
Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica
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DOI: 10.1038/s41598-017-15923-3
Abstract: The de novo L-cysteine biosynthetic pathway is critical for the growth, antioxidative stress defenses, and pathogenesis of bacterial and protozoan pathogens, such as Salmonella typhimurium and Entamoeba histolytica. This pathway involves two key enzymes, serine… read more here.
Keywords: protozoan; cysteine biosynthetic; novo cysteine; entamoeba histolytica ... See more keywords