Sticking it to KRAS: Covalent Inhibitors Enter the Clinic.
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DOI: 10.1016/j.ccell.2019.12.009
Abstract: Drugs that target KRAS 12C covalently, AMG 510 and MRTX849, are now in the clinic. Recent papers describe development of these compounds, their selectivity and properties, early clinical data, and potential combination therapies. These papers… read more here.
Keywords: sticking kras; covalent inhibitors; inhibitors enter; enter clinic ... See more keywords