AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9139-6_24
Abstract: The enteric nervous system of the lower gastrointestinal tract comprises intrinsic neural circuits as well as extrinsic afferent and efferent innervation. The development of strategies for neuronal gene transfer has created new opportunities for functional… read more here.
Keywords: nervous system; mediated gene; enteric nervous; aav mediated ... See more keywords
The enteric nervous system in gastrointestinal disease etiology
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03812-y
Abstract: A highly conserved but convoluted network of neurons and glial cells, the enteric nervous system (ENS), is positioned along the wall of the gut to coordinate digestive processes and gastrointestinal homeostasis. Because ENS components are… read more here.
Keywords: enteric nervous; nervous system; gastrointestinal disease; etiology ... See more keywords
Supporting Evidence of Human Enteric Nervous System Adult Neurogenesis: Presence of Primary Cilia and Adult Neurogenesis Markers.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-01017-8
Abstract: Adult neurogenesis has been profusely studied in central nervous system. However, its presence in enteric nervous system remains elusive although it has been recently demonstrated in mice and intimately linked to glial cells. Moreover, primary… read more here.
Keywords: neurogenesis; nervous system; adult neurogenesis; enteric nervous ... See more keywords
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon
Sign Up to like & getrecommendations! Published in 2021 at "Protein & Cell"
DOI: 10.1007/s13238-021-00835-w
Abstract: Axonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural connections and promotes detrimental disease defects. Here, we assessed the enteric nervous system (ENS) of the… read more here.
Keywords: sarm1; inflammation; colon; neurodegeneration ... See more keywords
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
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DOI: 10.1016/j.cell.2019.12.016
Abstract: Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we… read more here.
Keywords: immunity; nervous system; mucosal barrier; enteric nervous ... See more keywords
Benzophenone-3 induced abnormal development of enteric nervous system in zebrafish through MAPK/ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.130670
Abstract: Hirschsprung disease (HSCR) is a congenital disease characterized by the absence of enteric neurons, which is derived from the failure of the proliferation, differentiation or migration of the enteric neural crest cells (ENCCs). HSCR is… read more here.
Keywords: mapk erk; development enteric; nervous system; enteric nervous ... See more keywords
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.11.006
Abstract: Background & Aims Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for… read more here.
Keywords: mor; dor; functionally interact; enteric nervous ... See more keywords
scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.12.014
Abstract: Background and Aims Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate development of novel therapeutic approaches to treat devastating enteric… read more here.
Keywords: seq; neuron subtypes; nervous system; gdnf nrtn ... See more keywords
Impact of chemotherapy on gastrointestinal functions and the enteric nervous system.
Sign Up to like & getrecommendations! Published in 2017 at "Maturitas"
DOI: 10.1016/j.maturitas.2017.04.021
Abstract: Chemotherapy is the main treatment for many cancers, including colorectal cancer, a type of cancer with some of the highest prevalence and mortality rates worldwide. Although chemotherapeutic drugs have greatly improved the survival rates of… read more here.
Keywords: nervous system; chemotherapy induced; enteric nervous; side effects ... See more keywords
Enteric nervous system formation: disproportionate stochastic clonal expansion of a few initiating vagal neural crest cells
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.061
Abstract: Vascular network is first generated by vasculogenesis and angiogenesis. The vessel diameters are later modified by vascular flow, which is called remodeling process. Various theoretical models were proposed for this remodeling process to explain vascular… read more here.
Keywords: network; nervous system; formation; process ... See more keywords
Bisphenol A—Induced changes in the enteric nervous system of the porcine duodenum
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.03.008
Abstract: HighlightsBPA causes changes in the reproductive, nervous and immunological systems.BPA induces changes in the enteric nervous system.Tolerable daily intake of BPA causes changes in the duodenum.Tolerable daily intake of BPA requires further study. &NA; Bisphenol… read more here.
Keywords: bpa; nervous system; porcine duodenum; changes enteric ... See more keywords