Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver
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DOI: 10.1016/j.jff.2017.04.041
Abstract: Abstract Molecular and microbiome studies were employed to uncover the mechanisms underlying the cholesterol lowering effects of RC alkaloids. Hyperlipidemic mice were treated with RC alkaloids for 35 days. After treatment, bile acid levels in serum, liver… read more here.
Keywords: enterohepatic circulation; bile acids; gut; circulation bile ... See more keywords
Ripened Pu-Erh Tea Improved the Enterohepatic Circulation in a Circadian Rhythm Disorder Mice Model.
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DOI: 10.1021/acs.jafc.1c05338
Abstract: Glucolipid metabolism, nitrogen metabolism, and inflammation are closely related to circadian rhythm disorder (CRD). Ripened Pu-erh tea (RPT) shows significant antidyslipidemic, antihyperurecemic, and anti-inflammatory effects. However, it is unclear whether healthy population are affected by… read more here.
Keywords: enterohepatic circulation; crd; disorder; rpt ... See more keywords
Potential of ileal bile acid transporter inhibition as a therapeutic target in Alagille syndrome and progressive familial intrahepatic cholestasis
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DOI: 10.1111/liv.14553
Abstract: Alagille syndrome (ALGS) and progressive familial intrahepatic cholestasis (PFIC) are rare, inherited cholestatic liver disorders that manifest in infants and children and are associated with impaired bile flow (ie cholestasis), pruritus and potentially fatal liver… read more here.
Keywords: enterohepatic circulation; bile acids; inhibition; liver ... See more keywords
Peroxisome Proliferator-Activated Receptor-γ Prevents Cholesterol Gallstone Formation in C57bl Mice by Regulating Bile Acid Synthesis and Enterohepatic Circulation
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DOI: 10.1155/2018/7475626
Abstract: To investigate the role of the peroxisome proliferator-activated receptor-γ (PPARγ) in the progression of cholesterol gallstone disease (CGD), C57bl/6J mice were randomized to the following groups (n=7/group): L (lithogenic diet, LGD), LM (LGD+pioglitazone), CM (chow… read more here.
Keywords: enterohepatic circulation; ppar; circulation; cholesterol gallstone ... See more keywords