Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity
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DOI: 10.1021/acs.jmedchem.2c00463
Abstract: To discover a novel series of potent inhibitors of enteropeptidase, a membrane-bound serine protease localized to the duodenal brush border, 4-guanidinobenzoate derivatives were evaluated with minimal systemic exposure. The 1c docking model enabled the installation… read more here.
Keywords: novel series; enteropeptidase inhibitors; systemic exposure; guanidinobenzoate derivatives ... See more keywords