Rock1 is a novel host dependency factor of human enterovirus A71: Implication as a drug target
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27975
Abstract: Human enterovirus A71 (EV‐A71) is the major causative agent of hand‐foot‐and‐mouth disease (HFMD) commonly associated with severe neurological diseases, particularly in children under 5 years of age. Several investigational therapeutic agents and vaccine candidates are… read more here.
Keywords: human enterovirus; rock1; enterovirus a71; host ... See more keywords
Proteomic and metabonomic analysis uncovering Enterovirus A71 reprogramming host cell metabolic pathway
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202200362
Abstract: Enterovirus A71 (EV71) infection can cause hand, foot, and mouth disease (HFMD) and severe neurological complications in children. However, the biological processes regulated by EV71 remain poorly understood. Herein, proteomics and metabonomics studies were conducted… read more here.
Keywords: infection; glycolysis; enterovirus a71; ev71 infection ... See more keywords
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105683
Abstract: Enterovirus A71 (EV-A71), one of the major pathogens that causes hand, foot and mouth disease (HFMD), has seriously threatened the health and safety of young children. In this study, aminothiazole derivatives were synthesized and screened… read more here.
Keywords: aminothiazole derivatives; a71; enterovirus a71; a71 capsid ... See more keywords
Immunogenicity and safety of an inactivated enterovirus A71 vaccine in children 3-6 years and 2-35 months of age- an open-label, randomized phase IIb clinical trial.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.07.096
Abstract: BACKGROUND Enterovirus A71 (EV-A71) infection can cause severe debilitating complications and even death in young children. The immunogenicity and safety of an inactivated whole EV-A71 virus vaccine were assessed in children 2 months to 6 years of… read more here.
Keywords: enterovirus a71; part; age; safety ... See more keywords
Large-Scale Proteomic Identification of Targets of Cellular miR-197 Downregulated by Enterovirus A71.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00762
Abstract: MicroRNAs are noncoding RNA species comprising 18-23 nucleotides that regulate host-virus interaction networks. Here, we show that enterovirus A71 infection in human rhabdomyosarcoma (RD) is regulated by miR-197 expression. Transfection of miR-197 mimic into RD… read more here.
Keywords: enterovirus a71; large scale; scale proteomic; mir 197 ... See more keywords
Sodium Copper Chlorophyllin Is Highly Effective against Enterovirus (EV) A71 Infection by Blocking Its Entry into the Host Cell.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00096
Abstract: Human enteroviruses (HEVs) pose an ongoing threat to global public health. Particularly, enterovirus-A71 (EV-A71), the main pathogen causing hand-foot-and-mouth disease (HFMD), has caused ongoing outbreaks globally in recent years associated with severe neurological manifestations and… read more here.
Keywords: enterovirus a71; host cell; a71 infection; infection ... See more keywords
Assessing In Vitro Resistance Development in Enterovirus A71 in the Context of Combination Antiviral Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00872
Abstract: There are currently no antivirals available to treat infection with enterovirus A71 (EV-A71) or any other enterovirus. The extensively studied capsid binders rapidly select for drug-resistant variants. We here explore whether the combination of two… read more here.
Keywords: enterovirus a71; combination; enterovirus; resistance ... See more keywords
Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30631-2
Abstract: Enterovirus A71 (EV-A71) infection can induce encephalitis, which causes death or long-term neurological sequelae, especially in young children. Using a murine infection model, we searched for anti-EV-A71 agents, because effective therapies are not available to… read more here.
Keywords: enterovirus a71; infection; mice; ligand ... See more keywords
Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05904-6
Abstract: Infection with enterovirus-A71 (EV-A71) can cause hand-foot-mouth disease associated with fatal neurological complications. The host response to EV-A71 has not yet been fully elucidated, thus, hampering the development of a precise therapeutic approach. A nonstructural… read more here.
Keywords: response; enterovirus a71; a71; protein ... See more keywords
Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2028482
Abstract: ABSTRACT Numerous viruses manipulate host factors for viral production. We demonstrated that human enterovirus A71 (EVA71), a primary causative agent for hand, foot, and mouth disease (HFMD), increased the level of the DNA damage response… read more here.
Keywords: dna; h2ax; host; enterovirus a71 ... See more keywords
Estimating the Severity Profile of Enterovirus A71 Infections in Children: A Bayesian Synthesis Framework
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwy238
Abstract: Enterovirus A71 (EV-A71) is responsible for the majority of severe cases of hand, foot, and mouth disease, but little evidence is available on the severity profile of EV-A71 infections. We formulated a hierarchical Bayesian model… read more here.
Keywords: enterovirus a71; severity profile; a71; a71 infections ... See more keywords