Engineering the Entrance of a Flavonoid Glycosyltransferase Promotes the Glycosylation of Etoposide Aglycone.
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DOI: 10.1021/acssynbio.2c00032
Abstract: Enzyme entrances, which function as the first molecular filters, influence substrate selectivity and enzymatic activity. Because of low binding affinities, engineering enzyme entrances that recognize non-natural substrates is a major challenge for artificial biocatalyst design.… read more here.
Keywords: entrance flavonoid; flavonoid glycosyltransferase; etoposide aglycone; engineering ... See more keywords