Polyvalent 2D Entry Inhibitors for Pseudorabies and African Swine Fever Virus.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201600499
Abstract: African swine fever virus (ASFV) is one of the most dangerous viruses for pigs and is endemic in Africa but recently also spread into the Russian Federation and the Eastern border of the EU. So… read more here.
Keywords: swine fever; entry inhibitors; african swine; fever virus ... See more keywords
Flavivirus Entry Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-8702-0_11
Abstract: Flaviviruses, including Dengue virus, Zika virus, Yellow fever virus, Japanese encephalitis virus, West Nile virus, cause thousands of deaths and millions of illnesses each year. The large outbreak of ZIKV in 2016 reminds us that… read more here.
Keywords: entry; biology; entry inhibitors; virus ... See more keywords
Entry Inhibitors of Hepatitis B and D Viruses.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-8702-0_12
Abstract: Human hepatitis B virus (HBV) and hepatitis D virus (HDV) cause acute and chronic infections. The latter poses a serious public health threat as it is the major cause of chronic hepatitis, liver failure, cirrhosis,… read more here.
Keywords: hbv; inhibitors hepatitis; entry inhibitors; hdv ... See more keywords
Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00315
Abstract: We have recently described a new generation of potent human immunodeficiency virus (HIV) and EV-A71 entry inhibitors. The prototypes contain three or four tryptophan (Trp) residues bearing an isophthalic acid moiety at the C2 position… read more here.
Keywords: entry inhibitors; a71 entry; hiv; side chain ... See more keywords
Opening the door on entry inhibitors in HIV: Redefining the use of entry inhibitors in heavily treatment experienced and treatment‐limited individuals living with HIV
Sign Up to like & getrecommendations! Published in 2022 at "HIV Medicine"
DOI: 10.1111/hiv.13288
Abstract: Entry inhibitors are a relatively new class of antiretroviral therapy and are typically indicated in heavily treatment experienced individuals living with HIV. Despite this, there is no formal definition of ‘heavily treatment experienced’. Interpretation of… read more here.
Keywords: entry inhibitors; individuals living; treatment; treatment experienced ... See more keywords
Viral Entry Inhibitors Targeting Six-Helical Bundle Core Against Highly Pathogenic Enveloped Viruses with Class I Fusion Proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210511015808
Abstract: TypeⅠ enveloped viruses bind to cell receptors through surface glycoproteins to initiate infection or undergo receptor-mediated endocytosis. They also initiate membrane fusion in the acidic environment of endocytic compartments, releasing genetic material into the cell.… read more here.
Keywords: entry inhibitors; bundle; enveloped viruses; fusion ... See more keywords
In search of HIV entry inhibitors using molecular docking, ADME and toxicity studies of some Thiazolidinone-Pyrazine derivatives against CXCR4 co-receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Current HIV research"
DOI: 10.2174/1570162x20666220214123331
Abstract: BACKGROUND Entry inhibitors prevent binding of human immunodeficiency virus protein to the chemokine receptor CXCR4 and are used along with conventional anti-HIV therapy. They aid in restoring immunity and can prevent the development of HIV-TB… read more here.
Keywords: hiv; entry; entry inhibitors; toxicity ... See more keywords
SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21165707
Abstract: The pandemic evolution of SARS-CoV-2 infection is forcing the scientific community to unprecedented efforts to explore all possible approaches against COVID-19. In this context, targeting virus entry is a promising antiviral strategy for controlling viral… read more here.
Keywords: entry inhibitors; targeting virus; host; entry ... See more keywords
Quinolizidines as Novel SARS-CoV-2 Entry Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179659
Abstract: COVID-19, caused by the highly transmissible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has rapidly spread and become a pandemic since its outbreak in 2019. We have previously discovered that aloperine is a new privileged scaffold… read more here.
Keywords: quinolizidines novel; entry; entry inhibitors; cov entry ... See more keywords
Virtual Screening, Biological Evaluation, and 3D-QSAR Studies of New HIV-1 Entry Inhibitors That Function via the CD4 Primary Receptor
Sign Up to like & getrecommendations! Published in 2018 at "Molecules"
DOI: 10.3390/molecules23113036
Abstract: Human immunodeficiency virus type 1 (HIV-1) is responsible for the majority of HIV infections worldwide, and we still lack a cure for this infection. Blocking the interaction of HIV-1 and its primary receptor CD4 is… read more here.
Keywords: entry inhibitors; primary receptor; hiv entry; via cd4 ... See more keywords