Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.108959
Abstract: There is an urgent need for antivirals to treat the newly emerged SARS-CoV-2. To identify new candidates we screened a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antivirals, while screening in… read more here.
Keywords: entry pathways; drug; entry; sars cov ... See more keywords
Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
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DOI: 10.1038/s41467-017-02493-1
Abstract: AcrB is the major multidrug exporter in Escherichia coli. Although several substrate-entrances have been identified, the specificity of these various transport paths remains unclear. Here we present evidence for a substrate channel (channel 3) from… read more here.
Keywords: multidrug; transporter acrb; entry pathways; multiple entry ... See more keywords
Amyloid Beta Oligomers-Induced Ca2+ Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation
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DOI: 10.3390/biomedicines10051153
Abstract: The molecular basis of amyloid toxicity in Alzheimer’s disease (AD) remains controversial. Amyloid β (Aβ) oligomers promote Ca2+ influx, mitochondrial Ca2+ overload and apoptosis in hippocampal neurons in vivo and in vitro, but the primary… read more here.
Keywords: ca2 responses; entry pathways; nmda receptors; ca2 entry ... See more keywords