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   Articles with "entry pathways" as a keyword



Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

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recommendations! Published in 2021 at "Cell Reports"

DOI: 10.1016/j.celrep.2021.108959

Abstract: There is an urgent need for antivirals to treat the newly emerged SARS-CoV-2. To identify new candidates we screened a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antivirals, while screening in… read more here.

Keywords: entry pathways; drug; entry; sars cov ... See more keywords

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-02493-1

Abstract: AcrB is the major multidrug exporter in Escherichia coli. Although several substrate-entrances have been identified, the specificity of these various transport paths remains unclear. Here we present evidence for a substrate channel (channel 3)  from… read more here.

Keywords: multidrug; transporter acrb; entry pathways; multiple entry ... See more keywords

Exploring entry pathways of microorganisms into an anatomical dissection course

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-30667-1

Abstract: Anatomical dissection courses are central to medical education. Despite advances in fixation techniques, cadavers remain vulnerable to microbial contamination. Thus, we aimed to assess microbial entry pathways and discuss mitigation strategies in a dissection course… read more here.

Keywords: dissection; microbial load; dissection course; entry pathways ... See more keywords

Tradeoffs in viral fitness driven by alternative entry pathways

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recommendations! Published in 2025 at "mBio"

DOI: 10.1128/mbio.02833-25

Abstract: ABSTRACT Enveloped viruses can enter cells either through endocytosis or by direct fusion with the plasma membrane. The latter pathway often leads to syncytia formation, caused by the fusion of infected cells with neighboring receptor-bearing… read more here.

Keywords: entry; variant; fusion; cell ... See more keywords

Amyloid Beta Oligomers-Induced Ca2+ Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10051153

Abstract: The molecular basis of amyloid toxicity in Alzheimer’s disease (AD) remains controversial. Amyloid β (Aβ) oligomers promote Ca2+ influx, mitochondrial Ca2+ overload and apoptosis in hippocampal neurons in vivo and in vitro, but the primary… read more here.

Keywords: ca2 responses; entry pathways; nmda receptors; ca2 entry ... See more keywords