Viral internal ribosomal entry sites: four classes for one goal
Sign Up to like & getrecommendations! Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1458
Abstract: To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell entrance. Since viral genomes do not encode any components of the protein biosynthesis machinery, viral proteins must be produced by the host… read more here.
Keywords: viral internal; four classes; translation; viral proteins ... See more keywords
IRESpy: an XGBoost model for prediction of internal ribosome entry sites
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-2999-7
Abstract: BackgroundInternal ribosome entry sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and initiate translation independently of the 5′ cap-dependent translation initiation mechanism. IRES usually function when 5′ cap-dependent… read more here.
Keywords: ribosome entry; entry sites; model; xgboost model ... See more keywords
Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005734
Abstract: Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when… read more here.
Keywords: ribosome entry; ires activity; internal ribosome; activity ... See more keywords