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Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1458
Abstract: To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell entrance. Since viral genomes do not encode any components of the protein biosynthesis machinery, viral proteins must be produced by the host…
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Keywords:
viral internal;
four classes;
translation;
viral proteins ... See more keywords
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Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-2999-7
Abstract: BackgroundInternal ribosome entry sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and initiate translation independently of the 5′ cap-dependent translation initiation mechanism. IRES usually function when 5′ cap-dependent…
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Keywords:
ribosome entry;
entry sites;
model;
xgboost model ... See more keywords
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Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005734
Abstract: Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when…
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Keywords:
ribosome entry;
ires activity;
internal ribosome;
activity ... See more keywords