LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "env" as a keyword



HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage

Sign Up to like & get
recommendations! Published in 2017 at "Immunity"

DOI: 10.1016/j.immuni.2017.11.002

Abstract: SUMMARY Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV vaccine. Here, we described a bnAb lineage targeting the Env V2… read more here.

Keywords: lineage; heterogeneity; env; glycoform heterogeneity ... See more keywords
Photo from wikipedia

Cryo-EM structure of full-length HIV-1 Env bound with the Fab of antibody PG16.

Sign Up to like & get
recommendations! Published in 2020 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2019.11.028

Abstract: The HIV-1 envelope protein (Env) is the target of neutralizing antibodies and the template for vaccine immunogen design. The dynamic conformational equilibrium of trimeric Env influences its antigenicity and potential immunogenicity. Antibodies that bind at… read more here.

Keywords: cryo structure; hiv; fab; structure ... See more keywords

Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category.

Sign Up to like & get
recommendations! Published in 2018 at "Virology"

DOI: 10.1016/j.virol.2018.04.002

Abstract: HIV-1 virus entry into target cells requires the envelope glycoprotein (Env) to first bind the primary receptor, CD4 and subsequently the co-receptor. Antibody access to the co-receptor binding site (CoRbs) in the pre-receptor-engaged state, prior… read more here.

Keywords: cd4; binding site; receptor; receptor binding ... See more keywords

Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation

Sign Up to like & get
recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-04220-w

Abstract: Human immunodeficiency virus type 1 (HIV-1) assembly occurs on the inner leaflet of the host cell plasma membrane, incorporating the essential viral envelope glycoprotein (Env) within a budding lattice of HIV-1 Gag structural proteins. The… read more here.

Keywords: microscopy; hiv; envelope; env ... See more keywords

Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer

Sign Up to like & get
recommendations! Published in 2024 at "NPJ Vaccines"

DOI: 10.1038/s41541-024-01038-0

Abstract: Eliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine research. We characterized Ab1456 and Ab1271, two heterologously-neutralizing antibodies elicited in non-human primates by priming with an engineered… read more here.

Keywords: env trimers; neutralizing antibodies; env; antibodies elicited ... See more keywords

Priming VRC01-precursor B cells with non-envelope immunogens disfavors boosting with HIV-1 envelope

Sign Up to like & get
recommendations! Published in 2025 at "NPJ Vaccines"

DOI: 10.1038/s41541-025-01235-5

Abstract: VRC01-class antibodies are a genetically restricted class of antibodies capable of potently neutralizing diverse strains of HIV-1. Unmutated VRC01 precursors fail to recognize recombinant HIV-1 Envelope (Env) proteins, which necessitated the development of germline targeting… read more here.

Keywords: vrc01 class; envelope; class; vrc01 ... See more keywords

Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals.

Sign Up to like & get
recommendations! Published in 2019 at "AIDS research and human retroviruses"

DOI: 10.1089/aid.2019.0179

Abstract: To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral… read more here.

Keywords: infected indonesian; hiv; recently infected; derived recently ... See more keywords

Dynamic Evolution of Retroviral Envelope Genes in Egg-Laying Mammalian Genomes

Sign Up to like & get
recommendations! Published in 2022 at "Molecular Biology and Evolution"

DOI: 10.1093/molbev/msad090

Abstract: Independently acquired envelope (env) genes from endogenous retroviruses have contributed to the placental trophoblast cell-cell fusion in therian mammals. Egg-laying mammals (monotremes) are an important sister clade for understanding mammalian placental evolution, but the env… read more here.

Keywords: env; env tac1; evolution retroviral; egg laying ... See more keywords

CNSC-56. HUMAN ENDOGENOUS RETROVIRUS K ENV ACTIVATES CD98HC/EGFR SIGNALING TO PROMOTE GLIOBLASTOMA PROGRESSION

Sign Up to like & get
recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.0264

Abstract: Human endogenous retrovirus-K (HERV-K), particularly the HML-2 subtype, is the most recently integrated human provirus and remains transcriptionally active in several cancers, including glioblastoma (GBM). Although its function in GBM has been poorly defined, we… read more here.

Keywords: egfr; human endogenous; herv env; gbm ... See more keywords

Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

Sign Up to like & get
recommendations! Published in 2020 at "Journal of Virology"

DOI: 10.1128/jvi.00148-20

Abstract: The envelope glycoprotein (Env) spike on the surface of human immunodeficiency virus type 1 (HIV-1) mediates the entry of the virus into host cells and is also the target for antibodies. During virus entry, Env… read more here.

Keywords: conformation; virus; env; state ... See more keywords

Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function

Sign Up to like & get
recommendations! Published in 2019 at "Journal of Virology"

DOI: 10.1128/jvi.00304-19

Abstract: The human immunodeficiency virus type 1 (HIV-1) envelope proteins (Envs) bind receptors on the host cell and change shape to allow the virus to enter the cell. Most virus-inhibiting antibodies and drugs recognize a particular… read more here.

Keywords: conformation; envelope proteins; envelope; virus ... See more keywords