Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108122
Abstract: Summary BG505 SOSIP is a well-characterized near-native recombinant HIV Envelope (Env) trimer that holds promise as part of a sequential HIV immunogen regimen to induce broadly neutralizing antibodies (bnAbs). Rhesus macaques are considered the most… read more here.
Keywords: env trimer; rhesus; antibody; rhesus macaques ... See more keywords
Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006614
Abstract: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA Laboratory of… read more here.
Keywords: env trimer; hiv env; microscopy; conformational changes ... See more keywords
Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.27389
Abstract: The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2… read more here.
Keywords: env trimer; hiv envelope; recognition; v1v2 ... See more keywords