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   Articles with "env trimer" as a keyword



Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques

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recommendations! Published in 2020 at "Cell Reports"

DOI: 10.1016/j.celrep.2020.108122

Abstract: Summary BG505 SOSIP is a well-characterized near-native recombinant HIV Envelope (Env) trimer that holds promise as part of a sequential HIV immunogen regimen to induce broadly neutralizing antibodies (bnAbs). Rhesus macaques are considered the most… read more here.

Keywords: env trimer; rhesus; antibody; rhesus macaques ... See more keywords
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Conformational Changes in HIV-1 Env Trimer Induced by a Single CD4 as Revealed by Cryo-EM

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recommendations! Published in 2017 at "Microscopy and Microanalysis"

DOI: 10.1017/s1431927617006614

Abstract: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA Laboratory of… read more here.

Keywords: env trimer; hiv env; microscopy; conformational changes ... See more keywords

Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer

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recommendations! Published in 2024 at "NPJ Vaccines"

DOI: 10.1038/s41541-024-01038-0

Abstract: Eliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine research. We characterized Ab1456 and Ab1271, two heterologously-neutralizing antibodies elicited in non-human primates by priming with an engineered… read more here.

Keywords: env trimers; neutralizing antibodies; env; antibodies elicited ... See more keywords

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

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recommendations! Published in 2017 at "eLife"

DOI: 10.7554/elife.27389

Abstract: The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2… read more here.

Keywords: env trimer; hiv envelope; recognition; v1v2 ... See more keywords