A Cell-Cell Fusion Assay to Assess Arenavirus Envelope Glycoprotein Membrane-Fusion Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6981-4_10
Abstract: For many viruses that enter their target cells through pH-dependent fusion of the viral and endosomal membranes, cell-cell fusion assays can provide an experimental platform for investigating the structure-function relationships that promote envelope glycoprotein membrane-fusion… read more here.
Keywords: cell cell; cell fusion; envelope glycoprotein; fusion ... See more keywords
The cloning of the virus envelope glycoprotein F of canine distemper virus expressed in Pichia pastoris.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104094
Abstract: Canine distemper virus (CDV) is a pathogen which affects members of the Canidae family, causing an acute, often fatal, systemic disease. CDV is an RNA virus of the family Paramyxoviridae that contains two envelope glycoproteins:… read more here.
Keywords: envelope glycoprotein; canine distemper; pichia pastoris; distemper virus ... See more keywords
Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome
Sign Up to like & getrecommendations! Published in 2020 at "Virus Research"
DOI: 10.1016/j.virusres.2020.198222
Abstract: The envelope glycoprotein (E) is the smallest structural component of SARS-CoVs; plays an essential role in the viral replication starting from envelope formation to assembly. The in silico analysis of 2086 whole genome sequences from… read more here.
Keywords: envelope glycoprotein; terminal region; deletion; sars cov ... See more keywords
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1101-y
Abstract: The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic1–8. Imaging by single-molecule fluorescence resonance energy transfer (smFRET) has revealed that, on the surface of intact virions, mature pre-fusion Env transitions from… read more here.
Keywords: state; envelope glycoprotein; hiv; hiv envelope ... See more keywords
Cross-neutralizing CRF01_AE-infected Plasma from Malaysia Targets CD4-binding Site of Human Immunodeficiency Virus Type-1 (HIV-1) Envelope Glycoprotein.
Sign Up to like & getrecommendations! Published in 2021 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2020.0299
Abstract: HIV-1 antigenic variation poses a great challenge for vaccine immunogen design to elicit broadly neutralizing antibodies (bNAb). Over the last 10-15 years great progress has been made to understand the conserved sites of sensitivity on… read more here.
Keywords: hiv envelope; crf01 infected; hiv; cross ... See more keywords
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00094-21
Abstract: Roughly 32 million people have died as a consequence of HIV-1 infection since the start of the epidemic, and 1.7 million people still get infected with HIV-1 annually. Therefore, a vaccine to prevent HIV-1 infection… read more here.
Keywords: hiv; envelope glycoprotein; trimer; rabbits immunized ... See more keywords
Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00529-21
Abstract: The envelope glycoprotein (Env) trimers on the surface of human immunodeficiency virus (HIV-1) mediate the entry of the virus into host cells and serve as targets for neutralizing antibodies. The functional Env trimer is produced… read more here.
Keywords: trimer; virus; env; envelope glycoprotein ... See more keywords
HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00583-18
Abstract: Binding of the HIV envelope glycoprotein (Env) to cellular CD4 and chemokine receptors triggers conformational changes in Env that mediate virus entry, but premature triggering of Env conformational changes leads to virus inactivation. Currently, we… read more here.
Keywords: env conformational; envelope glycoprotein; gp120; resistance ... See more keywords
High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers
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DOI: 10.1128/jvi.00862-17
Abstract: ABSTRACT Soluble envelope glycoprotein (Env) trimers (SOSIP.664 gp140) are attractive HIV-1 vaccine candidates, with structures that mimic the native membrane-bound Env spike (gp160). Since engineering trimers can be limited by the difficulty of rationally predicting… read more here.
Keywords: engineering; envelope glycoprotein; protein engineering; stability ... See more keywords
Dual Pathways of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trafficking Modulate the Selective Exclusion of Uncleaved Oligomers from Virions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01369-20
Abstract: The envelope glycoprotein (Env) trimers on the surface of human immunodeficiency virus type 1 (HIV-1) mediate the entry of the virus into host cells and serve as targets for neutralizing antibodies. The cleaved, functional Env… read more here.
Keywords: surface; virus; cell; env ... See more keywords
Conformational Differences between Functional Human Immunodeficiency Virus Envelope Glycoprotein Trimers and Stabilized Soluble Trimers
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01709-18
Abstract: HIV-1 envelope glycoprotein spikes mediate the entry of the virus into host cells and are a major target for vaccine-induced antibodies. Soluble forms of the envelope glycoproteins that are stable and easily produced have been… read more here.
Keywords: envelope glycoprotein; envelope glycoproteins; envelope; hiv envelope ... See more keywords