Discovery of EGFR-Targeted Environment-Sensitive fluorescent probes for cell imaging and efficient tumor detection.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105585
Abstract: Overexpression of human epidermal growth factor receptor (EGFR) plays an important role in several signaling pathways inside and outside the cell, especially in the processes of cell proliferation, differentiation, and death in various cancers. Due… read more here.
Keywords: tumor; egfr; environment sensitive; probe ... See more keywords
Environment sensitive hydrogels for drug delivery applications
Sign Up to like & getrecommendations! Published in 2019 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2019.109220
Abstract: Abstract Over the last few decades, hydrogels have attracted the considerable interest of researchers for crafting potential controlled drug delivery systems. It may be attributed to their high water imbibing capacity, soft and rubbery nature,… read more here.
Keywords: drug; drug delivery; sensitive hydrogels; environment sensitive ... See more keywords
Discovery of Environment-Sensitive Fluorescent Ligands of β-Adrenergic Receptors for Cell Imaging and NanoBRET Assay.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05646
Abstract: By fusing several environment-sensitive fluorophores to the pharmacophore mirabegron, a series of new fluorescent ligands for β-adrenergic receptors (β-ARs) were produced with a turn-on mechanism and high binding affinity to β-ARs efficiently. Compound L5 with… read more here.
Keywords: ligands adrenergic; fluorescent ligands; environment; environment sensitive ... See more keywords
Environment-Sensitive Nucleoside Probe Unravels the Complex Structural Dynamics of i-Motif DNAs.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00237
Abstract: Although evidence for the existence and biological role of i-motif (iM) DNA structures in cells is emerging, probing their structural polymorphism and identifying physiologically active conformations using currently available tools remain a major challenge. Here,… read more here.
Keywords: environment sensitive; probe unravels; unravels complex; sensitive nucleoside ... See more keywords