Extended methods for gene–environment‐wide interaction scans in studies of admixed individuals with varying degrees of relationships
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DOI: 10.1002/gepi.22196
Abstract: The etiology of many complex diseases involves both environmental exposures and inherited genetic predisposition as well as interactions between them. Gene–environment‐wide interaction studies (GEWIS) provide a means to identify the interactions between genetic variation and… read more here.
Keywords: varying degrees; degrees relationships; environment wide; interaction ... See more keywords
Design and methodology challenges of environment-wide association studies: A systematic review.
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DOI: 10.1016/j.envres.2020.109275
Abstract: Environment-wide association studies (EWAS) are an untargeted, agnostic, and hypothesis-generating approach to exploring environmental factors associated with health outcomes, akin to genome-wide association studies (GWAS). While design, methodology, and replicability standards for GWAS are established,… read more here.
Keywords: methodology; association studies; environment wide; design methodology ... See more keywords
ENVIRONMENT-WIDE ASSOCIATION STUDY TO IDENTIFY NOVEL FACTORS ASSOCIATED WITH PERIPHERAL ARTERIAL DISEASE: EVIDENCE FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (1999-2004)
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DOI: 10.1016/s0735-1097(18)32633-0
Abstract: An environment-wide association study may be useful to test and validate associations between environmental factors and peripheral arterial disease (PAD) in an unbiased manner. Data from cross-sectional cohorts from National Health and Nutrition Examination Survey… read more here.
Keywords: environment wide; national health; association study; peripheral arterial ... See more keywords