A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
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DOI: 10.1016/j.cell.2017.05.010
Abstract: Summary Mutations truncating a single copy of the tumor suppressor, BRCA2, cause cancer susceptibility. In cells bearing such heterozygous mutations, we find that a cellular metabolite and ubiquitous environmental toxin, formaldehyde, stalls and destabilizes DNA… read more here.
Keywords: brca2 haploinsufficiency; haploinsufficiency; environmental endogenous; class environmental ... See more keywords