Individual and joint performance of DNA methylation profiles, genetic risk score and environmental risk scores for predicting breast cancer risk
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12594
Abstract: DNA methylation patterns in the blood, genetic risk scores (GRSs), and environmental risk factors can potentially improve breast cancer (BC) risk prediction. We assessed the individual and joint predictive performance of methylation, GRS, and environmental… read more here.
Keywords: methylation; risk; environmental risk; performance ... See more keywords
Caregiving Environmental Risk and Aggression From Infancy to Adolescence in a High-Risk Sample: An Examination of Between-Family and Within-Family Effects.
Sign Up to like & getrecommendations! Published in 2025 at "Aggressive behavior"
DOI: 10.1002/ab.70033
Abstract: The dynamic, longitudinal interplay between caregiving environmental risk (e.g., caregiver postnatal substance use and psychological symptoms, caregiving instability, exposure to violence) and child aggression is not well understood, particularly for substance-exposed children. A random intercept… read more here.
Keywords: child; family; risk; aggression ... See more keywords
Interaction of glutathione‐s‐transferase genotypes with environmental risk factors in determining susceptibility to head and neck cancer and treatment response and survival outcome
Sign Up to like & getrecommendations! Published in 2020 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22362
Abstract: The present case‐control study aimed to investigate the role of interaction of glutathione‐s‐transferase (GST) genotypes with environmental risk factors in determining susceptibility to head and neck squamous cell carcinoma (HNSCC) involving 1,250 cases and equal… read more here.
Keywords: risk; susceptibility; environmental risk; glutathione transferase ... See more keywords
Interaction of cytochrome P450s with environmental risk factors increases their expression and risk to head and neck cancer
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22495
Abstract: To investigate the role of interaction of tobacco metabolizing polymorphic cytochrome P450s (CYPs) and glutathione S‐transferase M1 (GSTM1) with environmental risk factors in modifying the susceptibility to head and neck squamous cell carcinoma (HNSCC), a… read more here.
Keywords: interaction; environmental risk; genotypes cyps; expression ... See more keywords
Alkylated Polycyclic Aromatic Compounds in Road Runoff Are an Environmental Risk and Should Be Included in Future Investigations
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5399
Abstract: Polycyclic aromatic compounds (PACs) and metals are important contaminants in road runoff. Vital mitigation measures against aquatic contamination from road runoff include the use of sedimentation ponds. However, it has been demonstrated that ecosystems in… read more here.
Keywords: sedimentation ponds; sedimentation; environmental risk; road runoff ... See more keywords
Environmental Risk Assessment of Time‐Variable Toxicant Exposure with Toxicokinetic–Toxicodynamic Modeling of Sublethal Endpoints and Moving Time Windows: A Case Study with Ceriodaphnia dubia
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5975
Abstract: Toxicokinetic–toxicodynamic (TKTD) modeling has received increasing attention in terms of the regulatory environmental risk assessment of chemicals. This type of mechanistic model can integrate all available data from individual‐level bioassays into a single framework and… read more here.
Keywords: exposure; time; risk; risk assessment ... See more keywords
Predictive accuracy of combined genetic and environmental risk scores
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22092
Abstract: The substantial heritability of most complex diseases suggests that genetic data could provide useful risk prediction. To date the performance of genetic risk scores has fallen short of the potential implied by heritability, but this… read more here.
Keywords: risk; environmental risk; accuracy; genetic environmental ... See more keywords
Environmental risk factors for inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2022 at "United European Gastroenterology Journal"
DOI: 10.1002/ueg2.12319
Abstract: Abstract Inflammatory bowel disease (IBD) is a chronic, progressive immune‐mediated inflammatory condition of the gastrointestinal tract. Environmental risk factors play a role in developing either type of IBD, Crohn's disease and ulcerative colitis; although the… read more here.
Keywords: environmental risk; disease; inflammatory bowel; risk factors ... See more keywords
In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1960-5_23
Abstract: This chapter aims to introduce the reader to the basic principles of environmental risk assessment of chemicals and highlights the usefulness of tiered approaches within weight of evidence approaches in relation to problem formulation i.e.,… read more here.
Keywords: risk assessment; assessment; environmental risk; tiered approaches ... See more keywords
Environmental risk factors for multiple sclerosis: a comprehensive systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurology"
DOI: 10.1007/s00415-025-13248-0
Abstract: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Its etiology may involve both genetic and environmental factors, including vitamin D levels, body mass index, infections, and smoking. This is the first… read more here.
Keywords: meta analysis; review; etiology; risk ... See more keywords
Environmental Risk of the Radiological Accidents at Chernobyl and Fukushima (Japan) NPP
Sign Up to like & getrecommendations! Published in 2017 at "Atomic Energy"
DOI: 10.1007/s10512-017-0236-x
Abstract: A comparative analysis of the levels of radioactive contamination of the environment on territories exposed to the accidental emissions from the Chernobyl and Fukushima (Japan) NPP is presented. An integral evaluation of the post-accident radio-ecological… read more here.
Keywords: risk; environmental risk; japan npp; risk radiological ... See more keywords