An enyne cycloisomerization/[5+1] reaction sequence to synthesize tetrahydroisoquinolinones from enyne-enes and CO.
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DOI: 10.1039/c6cc09925d
Abstract: An enyne cycloisomerization/[5+1] reaction sequence was developed to synthesize tetrahydroisoquinolinones from linear enyne-enes and CO. The first step is a gold(i)-catalyzed enyne cycloisomerization, generating six-membered-ring-fused vinylcyclopropanes. The second step is a rhodium(i)-catalyzed [5+1] reaction of… read more here.
Keywords: enyne cycloisomerization; cycloisomerization; reaction; reaction sequence ... See more keywords
Construction of the highly oxidized bicyclo[3.2.1]octane CD ring system of aconitine via a late stage enyne cycloisomerization.
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DOI: 10.1039/c8cc06819d
Abstract: A strategy for synthesizing the highly oxidized bicyclo[3.2.1]octane CD rings of aconitine is reported. The key features of the synthesis include a ring-closing metathesis to form the C-ring as well as the application of a… read more here.
Keywords: bicyclo octane; system aconitine; enyne cycloisomerization; highly oxidized ... See more keywords