Synthesis of Pyrroles Through the CuH-Catalyzed Coupling of Enynes and Nitriles.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c03859
Abstract: Herein, we describe an efficient method to prepare polysubstituted pyrroles via a copper-hydride (CuH)-catalyzed enyne-nitrile coupling reaction. This protocol accommodates both aromatic and aliphatic substituents and a broad range of functional groups, providing a variety… read more here.
Keywords: cuh catalyzed; enynes nitriles; synthesis pyrroles; catalyzed coupling ... See more keywords
Lewis/Brønsted acid-mediated cyclization/amidation of 1,6-enynes with nitriles: access to 3-enamide substituted dihydrobenzofurans.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00787a
Abstract: A novel Lewis- and Brønsted-acid mediated electrophilic addition cyclization/amidation reaction of 1,6-enynes with nitriles to synthesize 3-enamide-substituted dihydrobenzofurans has been developed. The transformation involves the addition of a Brønsted acid as the electrophilic reagent to… read more here.
Keywords: lewis nsted; acid mediated; nsted acid; cyclization ... See more keywords