Enzalutamide-induced and PTH1R-mediated TGFBR2 degradation in osteoblasts confers resistance in prostate cancer bone metastases.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.10.042
Abstract: Enzalutamide resistance has been observed in approximately 50% of patients with prostate cancer (PCa) bone metastases. Therefore, there is an urgent need to investigate the mechanisms and develop strategies to overcome resistance. We observed enzalutamide… read more here.
Keywords: bone metastases; enzalutamide resistance; prostate cancer; bone ... See more keywords
Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer.
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DOI: 10.1158/0008-5472.can-18-2812
Abstract: Castration-resistant prostate cancer (CRPC) that has developed resistance to the new-generation androgen receptor (AR) antagonist enzalutamide is a lethal disease. Transcriptome analysis of multiple prostate cancer models identified CXCR7, an atypical chemokine receptor, as one… read more here.
Keywords: cxcr7; prostate cancer; enzalutamide resistance; cancer ... See more keywords
A genome-wide CRISPR activation screen identifies PRRX2 as a regulator of enzalutamide resistance in prostate cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3565
Abstract: Androgen receptor (AR) pathway inhibitors are the mainstay treatment for advanced prostate cancer, but resistance to therapy is common. Here, we used a CRISPR activation screen in metastatic castration-sensitive prostate cancer cells to identify genes… read more here.
Keywords: enzalutamide resistance; cancer; resistance; prostate cancer ... See more keywords
Molecular underpinnings of enzalutamide resistance.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine-related cancer"
DOI: 10.1530/erc-17-0136
Abstract: Prostate cancer (PCa) is among the most common adult malignancies, and the second leading cause of cancer-related death in men. As PCa is hormone-dependent, blockade of the androgen receptor (AR) signaling is an effective therapeutic… read more here.
Keywords: enzalutamide resistance; resistance; cancer; molecular underpinnings ... See more keywords