Constructing multi‐enzymatic cascade reactions for selective production of 6‐bromoindirubin from tryptophan in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28188
Abstract: 6‐Bromoindirubin (6BrIR), found in Murex sea snails, is a precursor of indirubin‐derivatives anticancer drugs. However, its synthesis remains limited due to uncharacterized biosynthetic pathways and difficulties in site‐specific bromination and oxidation at the indole ring.… read more here.
Keywords: enzymatic cascade; multi enzymatic; escherichia coli; constructing multi ... See more keywords
Enzymatic Cascade in Pseudomonas that Produces Pyrazine from α‐Amino Acids
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900448
Abstract: Pyrazines are widespread chemical compounds that include pheromones and odors. Herein, a novel mechanism used by Pseudomonas fluorescens SBW25 to biosynthesize monocyclic pyrazines is reported. Heterologous expression of the papABC genes that synthesize the natural… read more here.
Keywords: amino; amino acids; produces pyrazine; enzymatic cascade ... See more keywords
A Bi‐Enzymatic Cascade Pathway towards Optically Pure FAHFAs **
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100070
Abstract: Recently discovered endogenous mammalian lipids, fatty acid esters of hydroxy fatty acids (FAHFAs), have been proved to have anti‐inflammatory and anti‐diabetic effects. Due to their extremely low abundancies in vivo, forging a feasible scenario for FAHFA… read more here.
Keywords: pathway towards; fatty acids; cascade pathway; enzymatic cascade ... See more keywords
Comparative copper toxicity impact and enzymatic cascade effect on Biosorption Activated Media and woodchips for nutrient removal in stormwater treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.09.062
Abstract: Copper, a commonly occurring heavy metal in stormwater runoff, was tested for its inhibitory effects on key nitrogen cycle bacteria in Biosorption Activated Media (BAM) and woodchip. The information in this paper is used to… read more here.
Keywords: copper; enzymatic cascade; cascade; stormwater ... See more keywords
Multicompartmental Microcapsules for Enzymatic Cascade Reactions Prepared through Gas Shearing and Surface Gelation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00324
Abstract: Inspired by the structure of eukaryotic cells, multicompartmental microcapsules have gained increasing attention. However, challenges remain in the fabrication of "all-aqueous" (i.e., oil-free) microcapsules composed of accurately adjustable hierarchical compartments. This study reports on multicompartmental… read more here.
Keywords: enzymatic cascade; gas shearing; multicompartmental microcapsules; cascade reactions ... See more keywords
Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03245
Abstract: Natural products are the greatest source of antimicrobial agents, although their structural complexity often renders synthetic production and diversification of key classes impractical. One pertinent example is the glycopeptide antibiotics (GPAs), which are highly challenging… read more here.
Keywords: evaluate tricyclization; precursor peptides; enzymatic cascade; cascade evaluate ... See more keywords
Closing the gap for efficient immobilization of biocatalysts in continuous processes: HaloTag™ fusion enzymes for a continuous enzymatic cascade towards a vicinal chiral diol
Sign Up to like & getrecommendations! Published in 2018 at "Green Chemistry"
DOI: 10.1039/c7gc03225k
Abstract: Compartmentalization of biocatalysts is an effective tool to integrate biocatalytic steps in continuous (chemo)enzymatic cascades. Therefore, efficient covalent immobilization techniques are of utmost importance, which enable a fast and selective immobilization of the enzyme directly… read more here.
Keywords: diol; immobilization; cascade; enzymatic cascade ... See more keywords
Constructing a photo-enzymatic cascade reaction and its in situ monitoring: enzymes hierarchically trapped in titania meso-porous MOFs as a new photosynthesis platform
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Materials Chemistry A"
DOI: 10.1039/d1ta04009j
Abstract: A photocatalysis-enzyme coupled system represents a most promising approach towards artificial photosynthesis and a direct use of solar energy for the synthesis of specific organic molecules or fuel. read more here.
Keywords: constructing photo; cascade reaction; enzymatic cascade; photosynthesis ... See more keywords
Ultrasensitive electrochemical biosensor for detection of circulating tumor cells based on a highly efficient enzymatic cascade reaction
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra01160g
Abstract: There has been great interest in the enzymatic cascade amplification strategy for the electrochemical detection of circulating tumor cells (CTCs). In this work, we designed a highly efficient enzymatic cascade reaction based on a multiwalled… read more here.
Keywords: enzymatic cascade; reaction; detection circulating; detection ... See more keywords
Efficient 2-Step Enzymatic Cascade for the Bioconversion of Oleuropein into Hydroxytyrosol
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020260
Abstract: Among the plant bioactive components, oleuropein (OLE) is the most abundant phenolic compound in all parts of olive trees (Olea europaea L.), particularly concentrated in olive leaves. It has been shown to present various remarkable… read more here.
Keywords: enzymatic cascade; step; step enzymatic; efficient step ... See more keywords
Chemo-Enzymatic Cascade for the Generation of Fragrance Aldehydes
Sign Up to like & getrecommendations! Published in 2021 at "Catalysts"
DOI: 10.3390/catal11080932
Abstract: In this study, we present the synthesis of chiral fragrance aldehydes, which was tackled by a combination of chemo-catalysis and a multi-enzymatic in vivo cascade reaction and the development of a highly versatile high-throughput assay… read more here.
Keywords: chemo enzymatic; fragrance aldehydes; fragrance; cascade generation ... See more keywords