Origin of Enzymatic Kinetic Isotope Effects in Human Purine Nucleoside Phosphorylase
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DOI: 10.1021/acscatal.7b04199
Abstract: Here we report a study of the effect of heavy isotope labeling on the reaction catalyzed by human purine nucleoside phosphorylase (hPNP) to elucidate the origin of its catalytic effect and of the enzymatic kinetic… read more here.
Keywords: purine nucleoside; human purine; isotope; enzymatic kinetic ... See more keywords
Enzymatic kinetic resolution of chiral sulfoxides - an enantiocomplementary approach.
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DOI: 10.1039/c9cc05470g
Abstract: A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO… read more here.
Keywords: sulfoxides enantiocomplementary; chiral sulfoxides; enantiocomplementary approach; kinetic resolution ... See more keywords
In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and β-Secretase Inhibitors with Antioxidant Properties
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DOI: 10.3390/antiox10050647
Abstract: The 5-(styryl)anthranilamides were transformed into the corresponding 5-styryl-2-(p-tolylsulfonamido)benzamide derivatives. These 5-styrylbenzamide derivatives were evaluated through enzymatic assays in vitro for their capability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase (BACE-1) activities as well as… read more here.
Keywords: kinetic studies; vitro enzymatic; drug; enzymatic kinetic ... See more keywords
Efficient and Stable Magnetic Chitosan-Lipase B from Candida Antarctica Bioconjugates in the Enzymatic Kinetic Resolution of Racemic Heteroarylethanols
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DOI: 10.3390/molecules25020350
Abstract: Lipase B from Candida antarctica immobilized by covalent binding on sebacoyl-activated chitosan-coated magnetic nanoparticles proved to be an efficient biocatalyst (49.2–50% conversion in 3–16 h and >96% enantiomeric excess) for the enzymatic kinetic resolution of… read more here.
Keywords: candida antarctica; kinetic resolution; enzymatic kinetic; racemic heteroarylethanols ... See more keywords
Simultaneous Enantiodivergent Synthesis of Diverse Lactones and Lactams via Sequential One-Pot Enzymatic Kinetic Resolution–Ring-Closing Metathesis Reactions
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DOI: 10.3390/molecules27227696
Abstract: One of the goals of diversity-oriented synthesis is to achieve the structural diversity of obtained compounds. As most biologically active compounds are chiral, it is important to develop enantioselective methods of their synthesis. The application… read more here.
Keywords: synthesis; one pot; resolution; enzymatic kinetic ... See more keywords