Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies.
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DOI: 10.1002/biot.201700381
Abstract: Antibodies are synthesized in mammalian cell culture as heterogeneous mixtures of glycoforms. Production of single glycoforms remains a challenge despite their value as therapeutics. The authors report a method of sequential enzymatic-based changes to antibodies… read more here.
Keywords: produces high; phase; enzymatic remodeling; solid phase ... See more keywords
On enzymatic remodeling of IgG glycosylation; unique tools with broad applications
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DOI: 10.1093/glycob/cwz085
Abstract: Abstract The importance of IgG glycosylation has been known for many years not only by scientists in glycobiology but also by human pathogens that have evolved specific enzymes to modify these glycans with fundamental impact… read more here.
Keywords: igg glycosylation; enzymatic remodeling; igg glycans; glycosylation ... See more keywords