Enzymatic, structural, and biophysical characterization of a single‐domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties
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DOI: 10.1002/pro.5227
Abstract: Human neutrophil elastase (hNE), a serine protease released by neutrophils during inflammation, plays a major role in the pathophysiology of several conditions especially in inflammatory lung diseases. Its inhibition constitutes, therefore, a promising therapeutic strategy… read more here.
Keywords: structural biophysical; enzymatic structural; neutrophil elastase; hne ... See more keywords