Enzymatic Synthesis Assisted Discovery of Proline‐Rich Macrocyclic Peptides in Marine Sponges
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DOI: 10.1002/cbic.202100275
Abstract: Proline‐rich macrocyclic peptides (PRMPs) are natural products present in geographically and phylogenetically dispersed marine sponges. The large diversity and low abundance of PRMPs in sponge metabolomes precludes isolation and structure elucidation of each individual PRMP… read more here.
Keywords: enzymatic synthesis; macrocyclic peptides; marine sponges; rich macrocyclic ... See more keywords
Enzymatic synthesis of fucose-containing galacto-oligosaccharides using β-galactosidase and identification of novel disaccharide structures
Sign Up to like & getrecommendations! Published in 2017 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-017-9794-3
Abstract: Fucosylated oligosaccharides have an important role in maintaining a healthy immune system and homeostatic gut microflora. This study employed a commercial β-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose. The production… read more here.
Keywords: enzymatic synthesis; product; containing galacto; fucose containing ... See more keywords
Enzymatic synthesis of vanillin catalysed by an eugenol oxidase
Sign Up to like & getrecommendations! Published in 2019 at "Applied Catalysis A: General"
DOI: 10.1016/j.apcata.2019.117117
Abstract: Abstract Vanillin is one of the most important flavours produced in the world. Due to its increasing value and its demand, mainly in the food industry, several ways to obtain it at lower prices are… read more here.
Keywords: vanillin; enzymatic synthesis; eugenol oxidase; vanillin catalysed ... See more keywords
Computational design of penicillin acylase variants with improved kinetic selectivity for the enzymatic synthesis of cefazolin
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2021.108149
Abstract: Abstract Enzymatic synthesis plays a pivotal role in the sustainable production of semi-synthetic β-lactam antibiotics. However, these types of green syntheses are being developed slowly because of a lack of appropriate enzymes. In the present… read more here.
Keywords: enzymatic synthesis; synthesis; kinetic selectivity; penicillin acylase ... See more keywords
Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate research"
DOI: 10.1016/j.carres.2017.05.002
Abstract: Corylifol A, a member of the isoflavone subclass of isoflavonoids, has long been considered to have various biological activities. Here, we sought to synthesize corylifol A glucosides by the in vitro glucosylation reaction using the UDP-glycosyltransferase… read more here.
Keywords: synthesis novel; udp glycosyltransferase; corylifol; enzymatic synthesis ... See more keywords
Enzymatic synthesis of non-natural trisaccharides and galactosides; Insights of their interaction with galectins as a function of their structure.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate research"
DOI: 10.1016/j.carres.2018.10.011
Abstract: Galectins are a family of carbohydrate-recognizing proteins that by interacting with specific glycoepitopes can mediate important biological processes, including immune cell homeostasis and activation of tolerogenic circuits. Among the different members of this family, Galectin… read more here.
Keywords: galp glcp; glcp; enzymatic synthesis; structure ... See more keywords
Dynamic enzymatic synthesis of γ-cyclodextrin using a photoremovable hydrazone template
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DOI: 10.1016/j.chempr.2021.05.013
Abstract: Summary The high water solubility of γ-cyclodextrin (γ-CD) lowers its synthetic yield and complicates its post-synthetic recovery, thus increasing production costs. Here, we report the use of a photoremovable hydrazone template as a proof-of-concept strategy… read more here.
Keywords: photoremovable hydrazone; cyclodextrin; template; enzymatic synthesis ... See more keywords
Enzymatic synthesis of sitagliptin intermediate using a novel ω-transaminase.
Sign Up to like & getrecommendations! Published in 2019 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2018.10.003
Abstract: Enantiopure β-amino acids are essential precursors of various pharmaceuticals, agrochemicals and other industrially important chemicals. In this study, we selected sixteen potential ω-Transaminases (ω-TAs) by BLAST and phylogenetic tree analysis. These ω-TAs were cloned, purified… read more here.
Keywords: amino; enzymatic synthesis; sitagliptin intermediate; synthesis ... See more keywords
Enzymatic synthesis of 1-o-galloylglycerol: Characterization and determination of its antioxidant properties.
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DOI: 10.1016/j.foodchem.2019.125479
Abstract: 1-o-Galloylglycerol (GG) was synthesized by the enzymatic glycerolysis of propyl gallate (PG) using a food-grade lipase (Lipozyme® 435). The reaction conditions affecting the yield of GG were optimized and a yield of 76.9% ± 1.2% was obtained.… read more here.
Keywords: galloylglycerol; antioxidant properties; enzymatic synthesis; synthesis galloylglycerol ... See more keywords
Inclusion of tributyrin during enzymatic synthesis of cyclodextrins by β-cyclodextrin glycosyltransferase from Bacillus circulans
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DOI: 10.1016/j.foodhyd.2019.105336
Abstract: Abstract Tributyrin is a precursor of butyric acid, which is beneficial to intestinal health. Due to its unpleasant odor and poor solubility, tributyrin is usually used after inclusion complexation with suitable wall materials. In this… read more here.
Keywords: synthesis; enzymatic synthesis; synthesis cyclodextrins; inclusion ... See more keywords
Enzymatic synthesis and tailoring lignin properties: A systematic study on the effects of plasticizers
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DOI: 10.1016/j.polymer.2020.122725
Abstract: Abstract This work elucidates for the first time the effects of incorporating various concentrations of plasticizers having different chain length on the mechanical properties of fully enzymatically-synthesized lignosulfonate-based materials (LigMat). Laccase extensively polymerized lignosulphonates from… read more here.
Keywords: synthesis tailoring; polymers supplemented; lignin; enzymatic synthesis ... See more keywords