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Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03708
Abstract: Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide…
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Keywords:
biosynthesis;
enzymatic total;
total synthesis;
one pot ... See more keywords
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Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b07161
Abstract: The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet-Spengler cyclizations. Herein we report concise and divergent chemo-enzymatic total syntheses of THIQ alkaloids by…
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Keywords:
jorunnamycin saframycin;
total syntheses;
enzymatic total;
chemo enzymatic ... See more keywords