Articles with "enzymatic total" as a keyword



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One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis.

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Published in 2017 at "Organic letters"

DOI: 10.1021/acs.orglett.6b03708

Abstract: Early acting cyclases play critical roles in programming the polyketide biosynthesis toward certain, distinguished scaffolds. Starting from acetyl-CoA and malonyl-CoA, a one-pot enzymatic total synthesis of an anthracyclinone scaffold, presteffimycinone, was achieved by mixing polyketide… read more here.

Keywords: biosynthesis; enzymatic total; total synthesis; one pot ... See more keywords
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Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3.

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Published in 2018 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.8b07161

Abstract: The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet-Spengler cyclizations. Herein we report concise and divergent chemo-enzymatic total syntheses of THIQ alkaloids by… read more here.

Keywords: jorunnamycin saframycin; total syntheses; enzymatic total; chemo enzymatic ... See more keywords