Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202509209
Abstract: Liquid–solid phase separation (LSPS) is a biomolecular segregation process forming solid‐like aggregates that encapsulate and concentrate specific biomolecules, thus profoundly influencing biochemical reactions. Building on this phenomenon, we developed an enzyme‐regulation strategy inducing LSPS of… read more here.
Keywords: separation; via microaggregates; phase separation; regulating enzyme ... See more keywords
Advanced Strategies of Enzyme Activity Regulation for Biomedical Applications
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200358
Abstract: Enzymes are important macromolecular biocatalysts that accelerate chemical and biochemical reactions in living organisms. Most human diseases are related to alterations in enzyme activity. Moreover, enzymes are potential therapeutic tools for treating different diseases, such… read more here.
Keywords: biomedical applications; enzyme activity; activity; advanced strategies ... See more keywords
Modulating Enzyme Activity using Engineered Nanomaterials
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400520
Abstract: Enzymes serve as pivotal components in various biotechnological applications across several industries. Understanding enzyme inhibition sheds light on how certain compounds disrupt biochemical pathways, facilitating the design of targeted drugs for combating diseases. On the… read more here.
Keywords: engineered nanomaterials; using engineered; modulating enzyme; enzyme activity ... See more keywords
Within‐species trade‐offs in plant‐stimulated soil enzyme activity and growth, flowering, and seed size
Sign Up to like & getrecommendations! Published in 2018 at "Ecology and Evolution"
DOI: 10.1002/ece3.4623
Abstract: Abstract Soil microbial communities affect species demographic rates of plants. In turn, plants influence the composition and function of the soil microbiome, potentially resulting in beneficial feedbacks that alter their fitness and establishment. For example,… read more here.
Keywords: soil; seed; plant; enzyme activity ... See more keywords
The effect of astaxanthin and cadmium on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzymes activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22170
Abstract: In this study, the effects of astaxanthin (AST) that belongs to carotenoid family and cadmium (Cd), which is an important heavy metal, on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzyme activities in vivo and… read more here.
Keywords: enzyme activity; 6pgd enzyme; rat erythrocyte; enzyme ... See more keywords
Recovery of enzyme activity in biotinidase deficient individuals during early childhood.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12490
Abstract: Deficiency of the biotinidase (BTD) enzyme is an inborn error of biotin metabolism caused by bi-allelic pathogenic variants in the BTD gene. There are two forms, partial and profound BTD deficiency, which both can be… read more here.
Keywords: recovery; deficiency; enzyme activity; btd ... See more keywords
Characterization of exonic variants of uncertain significance in very long‐chain acyl‐CoA dehydrogenase identified through newborn screening
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12492
Abstract: Very long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD) is an autosomal recessive disease resulting from mutations in the ACADVL gene and is among the disorders tested for in newborn screening (NBS). Confirmatory sequencing following suspected VLCADD NBS… read more here.
Keywords: acadvl; vlcad; enzyme activity; activity ... See more keywords
Novel mRNA therapy restores GALT protein and enzyme activity in a zebrafish model of classic galactosemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12512
Abstract: Messenger RNA (mRNA) has emerged as a novel therapeutic approach for inborn errors of metabolism. Classic galactosemia (CG) is an inborn error of galactose metabolism caused by a severe deficiency of galactose‐1‐phosphate:uridylyltransferase (GALT) activity leading… read more here.
Keywords: enzyme activity; zebrafish model; activity; activity zebrafish ... See more keywords
Ultrasound for pectinase modification: an investigation into potential mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10472
Abstract: BACKGROUND Today, ultrasound is increasingly utilized in enzyme modification. Strongly dependent on the specific operational conditions, the modification effect brought by ultrasound can be activation and inactivation of enzymes. This work aims to study the… read more here.
Keywords: enzyme activity; free radical; effect; ultrasound intensity ... See more keywords
Effect of metabolosome encapsulation peptides on enzyme activity, coaggregation, incorporation, and bacterial microcompartment formation
Sign Up to like & getrecommendations! Published in 2020 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1010
Abstract: Metabolosomes, catabolic bacterial microcompartments (BMCs), are proteinaceous organelles that are associated with the breakdown of metabolites such as propanediol and ethanolamine. They are composed of an outer multicomponent protein shell that encases a specific metabolic… read more here.
Keywords: protein; enzyme activity; formation; effect ... See more keywords
Effects of biochar adsorption on extracellular enzymes activity: measurement and interpretation
Sign Up to like & getrecommendations! Published in 2025 at "Soil Science Society of America Journal"
DOI: 10.1002/saj2.70123
Abstract: Extracellular enzymes play a key role in microbe‐mediated organic matter decomposition in soils, and the efficiency of these enzymes in substrate decomposition depends on their mobility and specific activity in soils. In this work, we… read more here.
Keywords: biochar adsorption; adsorption extracellular; adsorption; extracellular enzymes ... See more keywords