Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates
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DOI: 10.1021/acscatal.9b00780
Abstract: The enzyme 4-oxalocrotonate tautomerase (4-OT) exploits an N-terminal proline as main catalytic residue to facilitate several promiscuous C–C bond-forming reactions via enzyme-bound enamine intermediates. Here we show that the active site of this enzyme can… read more here.
Keywords: unsaturated aldehydes; enzyme bound; enzyme; asymmetric michael ... See more keywords