A Multifunctional Enzyme Cascade Catalytic Nanoplatform for Effective Synergistic Therapy of Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202423054
Abstract: Insufficient oxygen supply and elevated levels of reactive oxygen species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation and accelerate disease progression. In this study, a hybrid nanoassembly composed of superoxide dismutase (SOD) and… read more here.
Keywords: therapy; multifunctional enzyme; psc igu; rheumatoid arthritis ... See more keywords
MOF‐Immobilized Two‐in‐One Engineered Enzymes Enhancing Activity of Biocatalytic Cascade for Tumor Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203035
Abstract: Biocatalytic systems based on enzyme cascade reactions have attracted growing interest in the field of biocatalytic medicine. However, it is a major challenge to reasonably construct enzyme cascade reactions with high stability, selectivity, and catalytic… read more here.
Keywords: enzyme cascade; gox fe0; two one; cascade ... See more keywords
Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507481
Abstract: Periodontitis is a chronic inflammatory disease characterized by hypoxia, excessive oxidative stress, and immune dysregulation, leading to tissue destruction and bone resorption. Although antioxidants can reduce ROS and inflammation, most lack specificity and have a… read more here.
Keywords: enzyme; periodontitis treatment; natural enzyme; enzyme cascade ... See more keywords
Spore‐displayed enzyme cascade with tunable stoichiometry
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2416
Abstract: Taking the advantages of inert and stable nature of endospores, we developed a biocatalysis platform for multiple enzyme immobilization on Bacillus subtilis spore surface. Among B. subtilis outer coat proteins, CotG mediated a high expression… read more here.
Keywords: spore surface; stoichiometry; enzyme cascade; spore displayed ... See more keywords
Flexible Assembly of an Enzyme Cascade on a DNA Triangle Prism Nanostructure for the Controlled Biomimetic Generation of Nitric Oxide
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800337
Abstract: Spatial organization of multiple enzymes at specific positions for a controlled reaction cascade has attracted wide attention in recent years. Here, we report the construction of a biomimetic enzyme cascade organized on DNA triangle prism… read more here.
Keywords: dna; enzyme cascade; enzyme; generation ... See more keywords
High-Performance Integrated Enzyme Cascade Bioplatform Based on Protein-BiPt Nanochain@Graphene Oxide Hybrid Guided One-Pot Self-Assembly Strategy.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201804987
Abstract: Nanozymes provide new opportunities for facilitating next generation artificial enzyme cascade platforms. However, the fabrication of high-performance integrated artificial enzyme cascade (IAEC) bioplatforms based on nanozymes remains a great challenge. A facile and effective self-assembly… read more here.
Keywords: performance integrated; self assembly; assembly strategy; enzyme cascade ... See more keywords
Enzyme Cascade with Horseradish Peroxidase Readout for High-Throughput Screening and Engineering of Human Arginase-1.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05429
Abstract: We report an enzyme cascade with horseradish peroxidase-based readout for screening human arginase-1 (hArg1) activity. We combined the four enzymes hArg1, ornithine decarboxylase, putrescine oxidase, and horseradish peroxidase in a reaction cascade that generated colorimetric… read more here.
Keywords: enzyme cascade; human arginase; horseradish peroxidase; arginase ... See more keywords
PtNPs as Scaffolds to Regulate Interenzyme Distance for Construction of Efficient Enzyme Cascade Amplification for Ultrasensitive Electrochemical Detection of MMP-2.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b02210
Abstract: The high catalytic efficiency of enzyme cascade reaction mainly depends on optimal interenzyme distance regulated by the special scaffolds. In this work, the rigid PtNPs with different sizes were employed as scaffolds to regulate interenzyme… read more here.
Keywords: interenzyme distance; enzyme cascade; ptnps; enzyme ... See more keywords
Biosynthesis of Human Milk Oligosaccharides: Enzyme Cascade and Metabolic Engineering Approaches.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08436
Abstract: Human milk oligosaccharides (HMOs) have unique beneficial effects for infants and are considered as the new gold standard for premium infant formula. They are a collection of unconjugated glycans, and more than 200 distinct structures… read more here.
Keywords: milk oligosaccharides; human milk; metabolic engineering; enzyme cascade ... See more keywords
Exquisite Enzyme-Fenton Biomimetic Catalysts for Hydroxyl Radical Production by Mimicking an Enzyme Cascade.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b18690
Abstract: Hydrogen peroxide (H2O2) is a key reactant in the Fenton process. As a byproduct of enzymatic reaction, H2O2 can be obtained via catalytical oxidation of glucose using glucose oxidase in the presence of O2. Another… read more here.
Keywords: production; enzyme cascade; mimicking enzyme; reaction ... See more keywords
Multilayer Engineering of Enzyme Cascade Catalysis for One-Pot Preparation of Nylon Monomers from Renewable Fatty Acids
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b05426
Abstract: Enzyme cascade catalysis has critical problems in obtaining the high concentrations of products, such as the low stabilities and activities of biocatalysts and the inhibition by hydrophobic reactan... read more here.
Keywords: enzyme cascade; catalysis; engineering enzyme; cascade catalysis ... See more keywords