Near-infrared II plasmonic tri-enzyme integrated metal-organic frameworks with high-efficiency enzyme cascades for synergistic tri-modal oncotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202200871
Abstract: Natural enzyme-based catalytic cascades hold great promise for cancer therapy, but their clinical utility is greatly hindered by the loss of their functions during in vivo delivery. Herein, we report a plasmonic tri-enzyme integrated metal-organic… read more here.
Keywords: therapy; tri enzyme; high efficiency; enzyme cascades ... See more keywords
Nucleic‐Acid‐Templated Enzyme Cascades
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201600703
Abstract: Cellular metabolism involves complex sequences of organized enzymatic reactions, known as metabolic pathways, that convert substrates into readily usable materials. In nature, these enzymatic complexes are organized in a well‐defined manner so that the cascade… read more here.
Keywords: enzyme cascades; acid templated; enzyme; templated enzyme ... See more keywords
Whole-cell based synthetic enzyme cascades-light and shadow of a promising technology.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2018.10.016
Abstract: Mimicking Nature by biocatalytic cascade reactions in a whole-cell environment is a revolutionary development in multistep synthesis for the production of bulk and fine chemicals. In the past decade, several proof of concept success stories… read more here.
Keywords: synthetic enzyme; enzyme cascades; based synthetic; whole cell ... See more keywords
From Protein Film Electrochemistry to Nanoconfined Enzyme Cascades and the Electrochemical Leaf
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Reviews"
DOI: 10.1021/acs.chemrev.2c00397
Abstract: Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox proteins and many electron-transferring enzymes, allowing investigations of otherwise ill-defined or intractable topics such as unstable Fe–S centers and the catalytic bias… read more here.
Keywords: enzyme cascades; electrochemistry; film electrochemistry; leaf ... See more keywords
Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines
Sign Up to like & getrecommendations! Published in 2017 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b00513
Abstract: The increasing diversity of reactions mediated by biocatalysts has led to development of multistep in vitro enzyme cascades, taking advantage of generally compatible reaction conditions. The construction of pathways within single whole cell systems is… read more here.
Keywords: enzyme cascades; cells synthesis; whole cell; synthesis chiral ... See more keywords
De novo biosynthesis of (S)- and (R)-phenylethanediol in yeast via artificial enzyme cascades.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00123
Abstract: Due to the oil depletion and global climate change, sustainable manufacturing of fine chemicals from renewable feedstocks has gained an increasing attention in the scientific community. In the present study, we attempted to engineer Saccharomyces… read more here.
Keywords: enzyme cascades; novo biosynthesis; artificial enzyme; styrene ... See more keywords
The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20403-w
Abstract: Multistep enzyme-catalyzed cascade reactions are highly efficient in nature due to the confinement and concentration of the enzymes within nanocompartments. In this way, rates are exceptionally high, and loss of intermediates minimised. Similarly, extended enzyme… read more here.
Keywords: enzyme cascades; nanoconfinement energising; power electrified; enzyme ... See more keywords
Peptide-induced super-assembly of biocatalytic metal–organic frameworks for programmed enzyme cascades† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02021g
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc02021g
Abstract: Complementary peptide-induced super-assembly of biocatalytic MOFs is developed for programmed enzyme cascades on demand. read more here.
Keywords: super assembly; enzyme cascades; induced super; peptide induced ... See more keywords
Industrially Relevant Enzyme Cascades for Drug Synthesis and Their Ecological Assessment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073605
Abstract: Environmentally friendly and sustainable processes for the production of active pharmaceutical ingredients (APIs) gain increasing attention. Biocatalytic synthesis routes with enzyme cascades support many stated green production principles, for example, the reduced need for solvents… read more here.
Keywords: industrially relevant; synthesis; enzyme cascades; cascades drug ... See more keywords