A dual-enzyme cleavable linker for antibody-drug conjugates.
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DOI: 10.1039/d1cc00957e
Abstract: A novel enzyme cleavable linker for antibody-drug conjugates is reported. The 3-O-sulfo-β-galactose linker is cleaved sequentially by two lysosomal enzymes - arylsulfatase A and β-galactosidase - to release the payload in targeted cells. An α-HER2… read more here.
Keywords: linker antibody; enzyme cleavable; linker; antibody drug ... See more keywords