Improving lysine production through construction of an Escherichia coli enzyme‐constrained model
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DOI: 10.1002/bit.27485
Abstract: Microbial cell factories are widely used for the production of high‐value chemicals. However, maximizing production titers is made difficult by the complicated regulatory mechanisms of these cell platforms. Here, kcat values were incorporated to construct… read more here.
Keywords: coli enzyme; production; escherichia coli; enzyme constrained ... See more keywords
Enzyme‐constrained models predict the dynamics of Saccharomyces cerevisiae growth in continuous, batch and fed‐batch bioreactors
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13995
Abstract: Genome‐scale, constraint‐based models (GEM) and their derivatives are commonly used to model and gain insights into microbial metabolism. Often, however, their accuracy and predictive power are limited and enable only approximate designs. To improve their… read more here.
Keywords: batch; growth; models predict; enzyme constrained ... See more keywords
Enzyme-constrained metabolic model of Treponema pallidum identified glycerol-3-phosphate dehydrogenase as an alternate electron sink
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DOI: 10.1128/msystems.01555-24
Abstract: ABSTRACT Treponema pallidum, the causative agent of syphilis, poses a significant global health threat. Its strict reliance on host-derived nutrients and difficulties in in vitro cultivation have impeded detailed metabolic characterization. In this study, we… read more here.
Keywords: host; metabolic model; model; treponema pallidum ... See more keywords
Construction and Analysis of an Enzyme-Constrained Metabolic Model of Corynebacterium glutamicum
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DOI: 10.3390/biom12101499
Abstract: The genome-scale metabolic model (GEM) is a powerful tool for interpreting and predicting cellular phenotypes under various environmental and genetic perturbations. However, GEM only considers stoichiometric constraints, and the simulated growth and product yield values… read more here.
Keywords: corynebacterium glutamicum; enzyme constrained; glutamicum; model ... See more keywords