Targeted enzyme delivery systems in lysosomal disorders: an innovative form of therapy for mucopolysaccharidosis
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03135-z
Abstract: Mucopolysaccharidoses (MPSs), which are inherited lysosomal storage disorders caused by the accumulation of undegraded glycosaminoglycans, can affect the central nervous system (CNS) and elicit cognitive and behavioral issues. Currently used enzyme replacement therapy methodologies often… read more here.
Keywords: targeted enzyme; systems lysosomal; delivery systems; enzyme delivery ... See more keywords
Virus-Derived Peptides for Hepatic Enzyme Delivery.
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DOI: 10.1021/acs.molpharmaceut.0c01222
Abstract: Recently, a lipopeptide derived from the hepatitis B virus (HBV) large surface protein has been developed as an HBV entry inhibitor. This lipopeptide, called MyrcludexB (MyrB), selectively binds to the sodium taurocholate cotransporting polypeptide (NTCP)… read more here.
Keywords: enzyme delivery; hrp; virus derived; hrp myrb ... See more keywords
Defect-free graphene enhances enzyme delivery to fibroblasts derived from patients with lysosomal storage disorders.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr04971f
Abstract: Enzyme replacement therapy shows remarkable clinical improvement in treating lysosomal storage disorders. However, this therapeutic approach is hampered by limitations in the delivery of the enzyme to cells and tissues. Therefore, there is an urgent,… read more here.
Keywords: graphene; storage disorders; enzyme delivery; lysosomal storage ... See more keywords