Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras
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DOI: 10.1126/sciadv.abq2216
Abstract: Epigenetic mediation through bromodomain and extraterminal (BET) proteins have progressively translated protein imbalance into effective cancer treatment. Perturbation of druggable BET proteins through proteolysis-targeting chimeras (PROTACs) has recently contributed to the discovery of effective therapeutics.… read more here.
Keywords: derived clicking; hypoxia deactivates; enzyme; enzyme derived ... See more keywords