An Enzyme-Directed Imidazoquinoline Activated by Drug Resistance.
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DOI: 10.1021/acs.biochem.8b00095
Abstract: Drug efflux and enzymatic drug degradation are two cellular mechanisms that contribute to drug resistance in many cancers. Herein, we report the synthesis and in vitro activity of a pro-immunostimulant that exploits both processes in… read more here.
Keywords: drug; drug resistance; drug efflux; enzyme directed ... See more keywords