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   Articles with "enzyme engineering" as a keyword



Current Advances in the Enzyme Engineering of O2‐Dependent Enzymes – Boosting the Versatility and Applicability of Oxygenases and Oxidases

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recommendations! Published in 2024 at "ChemCatChem"

DOI: 10.1002/cctc.202301109

Abstract: Oxidation reactions catalysed by O2‐dependent enzymes are gaining increasing interest in the chemical industry due to their potential to provide a more selective and sustainable alternative to conventional chemical oxidation methods. O2‐dependent enzymes, like oxidases… read more here.

Keywords: enzyme engineering; engineering dependent; engineering; advances enzyme ... See more keywords
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Cell-free synthetic biology in the new era of enzyme engineering

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recommendations! Published in 2020 at "Chinese Journal of Chemical Engineering"

DOI: 10.1016/j.cjche.2020.05.037

Abstract: Abstract With the gradual rise of enzyme engineering, it has played an essential role in synthetic biology, medicine, and biomanufacturing. However, due to the limitation of the cell membrane, the complexity of cellular metabolism, the… read more here.

Keywords: engineering; enzyme engineering; biology; cell free ... See more keywords

Enzyme engineering: reaching the maximal catalytic efficiency peak.

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recommendations! Published in 2017 at "Current opinion in structural biology"

DOI: 10.1016/j.sbi.2017.09.002

Abstract: The practical need for highly efficient enzymes presents new challenges in enzyme engineering, in particular, the need to improve catalytic turnover (kcat) or efficiency (kcat/KM) by several orders of magnitude. However, optimizing catalysis demands navigation… read more here.

Keywords: maximal catalytic; peak; catalytic efficiency; efficiency ... See more keywords

Enzyme Engineering Renders Chlorinase the Activity of Fluorinase.

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recommendations! Published in 2024 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.3c08185

Abstract: Organofluorine compounds have attracted substantial attention owing to their wide application in agrochemistry. Fluorinase (FlA) is a unique enzyme in nature that can incorporate fluorine into an organic molecule. Chlorinase (SalL) has a similar mechanism… read more here.

Keywords: fla; engineering renders; enzyme engineering; fluorinase ... See more keywords

Structure and Cooperativity in Substrate-Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.1c00500

Abstract: Enzyme-based synthetic chemistry provides a green way to synthesize industrially important chemical scaffolds and provides incomparable substrate specificity and unmatched stereo-, regio-, and chemoselective product formation. However, using biocatalysts at an industrial scale has its… read more here.

Keywords: cooperativity; substrate enzyme; structure; protein engineering ... See more keywords

Accelerated enzyme engineering by machine-learning guided cell-free expression

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-55399-0

Abstract: Enzyme engineering is limited by the challenge of rapidly generating and using large datasets of sequence-function relationships for predictive design. To address this challenge, we developed a machine learning (ML)-guided platform that integrates cell-free DNA… read more here.

Keywords: enzyme engineering; cell free; guided cell; machine learning ... See more keywords

Pathway and enzyme engineering for the bioconversion of lignin derivatives into homoeriodictyol in Saccharomyces cerevisiae

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recommendations! Published in 2024 at "Green Chemistry"

DOI: 10.1039/d4gc00183d

Abstract: A sustainable lignin bioconversion depends on the exploitation of the inherent aromaticity of lignin for high-value aromatic products. However, the microbial valorization of lignin is hindered by the lack of... read more here.

Keywords: engineering bioconversion; enzyme engineering; lignin; bioconversion lignin ... See more keywords

Biosensor-based enzyme engineering approach applied to psicose biosynthesis

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recommendations! Published in 2019 at "Synthetic Biology"

DOI: 10.1093/synbio/ysz028

Abstract: Abstract Bioproduction of chemical compounds is of great interest for modern industries, as it reduces their production costs and ecological impact. With the use of synthetic biology, metabolic engineering and enzyme engineering tools, the yield… read more here.

Keywords: engineering; based enzyme; biology; enzyme engineering ... See more keywords